Arifah, Nina Nur (2018) Korelasi Skor Hasford dengan Respons Terapi Imatinib mesylate Pada Pasien Leukemia Granulositik Kronik. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Tujuan terapi leukemia granulositik kronis adalah tercapainya Latar Belakang: Tujuan terapi leukemia granulositik kronis adalah tercapainya remisi komplit, baik remisi hematologi, sitogenetika, maupun molekuler. Sistem prognostik diperlukan dalam membantu memilih terapi secara efisien, salah satunya adalah skor Hasford. Penelitian ini dilakukan untuk melihat korelasi skor Hasford dengan respons terapi Imatinib mesylate pada pasien LGK di kota Malang. Metode: Penelitian ini dilakukan dengan metode survei. Data diambil secara retrospektif berdasarkan rekam medis. Populasi adalah pasien LGK fase kronis yang menerima terapi Imatinib mesylate sekurang-kurangnya 18 bulan di Instalasi Rawat Jalan RSUD Saiful Anwar Malang. Penghitungan skor Hasford dilakukan dengan menggunakan data saat pertama kali pasien menerima Imatinib. Hasil penelitian disajikan secara deskriptif serta dianalisis secara korelasi. Analisis respons terapi dilakukan dengan Uji Chi Square, sedangkan penilaian resistensi dilakukan dengan luas kurva ROC. Hasil: Pada penelitian ini, didapatkan 51 pasien dengan 2 pasien berada di skor Hasford risiko rendah, 20 pasien risiko sedang dan 29 pasien risiko tinggi. Korelasi bermakna didapatkan pada respons hematologi pada bulan ketiga dan keenam (p masing-masing 0.040, 0.020), serta pada respons molekuler pada bulan kedua belas (p=0.049). Resistensi Imatinib mesylate dapat diperkirakan dengan skor Hasford dengan luas kurva ROC sebesar 0.811 dan 95% CI sebesar 0.613 - 1.009 (p=0.014). Cut of value dalam menentukan resisten atau non-resisten terhadap Imatinib adalah 1284.338, di mana skor Hasford < 1284.338 termasuk dalam kategori non-resisten dan sebaliknya. Kesimpulan: Skor Hasford berkorelasi terhadap respons hematologi dan molekuler pada pasien LGK yang diterapi Imatinib mesylate serta kemungkinan resistensi terhadap agen tersebut
English Abstract
Background: The goal of chronic myeloid leukemia therapy is achieving complete hematologic, cytogenetic, or molecular remission. A prognostic system were needed in choosing therapy efficiently, one of which is Hasford's score. This study was conducted to see the correlation of Hasford score with the response of Imatinib mesylate therapy in LGK patients in Malang. Method: This research was conducted by survey method. Data were retrospectively took based on medical records. The population was chronic phase CML patients who received Imatinib mesylate therapy for at least 18 months at the Outpatient Installation of Saiful Anwar Hospital Malang. Hasford score was calculated using data when the patient received Imatinib for the first time. Analysis of therapeutic response was done by Chi Square, while resistance assessment was calculated using ROC curve area. Results: Fifty one CML patients were included, there were 2, 20, and 29 patients in low, intermediate and high risk of Hasford score respectively. Significant correlations were obtained in hematologic responses in the third and sixth months (p: 0.040 and 0.020 respectively), and also in the molecular response in the twelfth month (p = 0.049). Imatinib mesylate resistance can be estimated by Hasford score with ROC curve area of 0.811 and 95% CI of 0.613 - 1.009 (p = 0.014). The cut off value in determining whether resistant or non-resistant to Imatinib is 1284.338, where Hasford score <1284.338 belongs to the nonresistant category and vice versa. Conclusion: Hasford's score correlates to both haematological and molecular responses in CML patients treated with Imatinib mesylate as well as possible resistance to this agent.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/362.196 994 19/ARI/k/2018/041803774 |
| Uncontrolled Keywords: | LEUKIMIA - SOCIAL SERVECES |
| Subjects: | 300 Social sciences > 362 Social problems of and services to groups of people > 362.1 People with physical illnesses > 362.19 Services to patients with specific conditions > 362.196 994 19 Specific conditions (Leukemia) |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | Nur Cholis |
| Date Deposited: | 02 Apr 2019 06:46 |
| Last Modified: | 22 Oct 2021 03:45 |
| URI: | http://repository.ub.ac.id/id/eprint/166433 |
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