Christiandari, Yunita (2011) Hubungan Antibodi Anticardiolipin dengan Manifestasi Klinis Trombosis pada Lupus Eritematosus Sistemik. Magister thesis, Universitas Brawijaya.
Abstract
Latar belakang. Antibodi anticardiolipin merupakan antibodi utama yang terkait dengan sindrom antifosfolipid, yang bermanifestasi klinis sebagai trombosis vaskular dan morbiditas kehamilan pada pasien dengan Lupus Eritematosus Sistemik. Banyak laporan yang mengkaitkan hubungan antibodi anticardiolipin dengan trombosis dan hasilnya masih kontroversi. Penelitian ini masih sangat sedikit dilakukan di Indonesia. Tujuan. Untuk mengetahui hubungan antara antibodi anticardiolipin dengan manifestasi klinis trombosis pada pasien lupus eritematosus sistemik di Bagian Reumatologi Rumah Sakit dr. Saiful Anwar, Malang. Metode. Diteliti 40 pasien dengan LES, didiagnosa menurut kriteria ACR 1997. Kadar serum ACA IgM dan IgG diukur dengan metode ELISA. Manifestasi klinis trombosis abortus berulang, stroke trombosis, iskemia jantung dan infark jantung diperoleh dari anamnesa, pemeriksaan klinis, pemeriksaan radiologis, dengan mengevaluasi foto toraks, CT Scan , USG, EKG, enzim jantung. Hasil. Pada 40 pasien LES yang dilakukan pemeriksaan ACA IgM dan IgG, didapatkan 3 orang (7,5%) dengan ACA IgM positip, dan 37 pasien (92,5%) dengan ACA IgM negatip, sedangkan pemeriksaan dengan ACA IgG tidak didapatkan pada seluruh pasien. Manifestasi klinis trombosis yang ditemukan meliputi terjadinya abortus pada 6 orang (15%), iskemia miokard 9 orang (22,5%), iskemia miokard dan abortus didapatkan pada 2 orang (5%), parese karena stroke 2 orang (5%). Kadar ACA IgM dengan manifestasi trombosis adalah 14,10±1,10 U/ml yang. Dari uji statistik didapatkan hubungan signifikan antara manifestasi klinis trombosis dengan kadar ACA IgM (r=0.362, p=0.021). Kesimpulan. Ada hubungan yang signifikan antara kadar antibodi anticardiolipin dengan manifestasi klinis trombosis pada pasien LES.
English Abstract
Background. Anticardiolipin antibody is main antibody associated with antiphospholipid syndrome, which manifests clinically as vascular thrombosis and pregnancy morbidity in patients with systemic lupus ery matosus. Many reports link relationship anticardiolipin antibodies with thrombosis and results are still controversial. This research is still very little is done in Indonesia. Objective. purpose of this cross-sectional study was to investigate correlation between anticardiolipin antibody with clinical manifestations of thrombosis in systemic lupus ery matosus patients at Rheumatology Departement of Saiful Anwar General Hospital, Malang. Methods. We studied 40 patients with SLE, diagnosed according to ACR criteria 1997. Serum IgM and IgG ACA were measured by ELISA method. Clinical manifestations of recurrent miscarriage thrombosis, stroke thrombosis, cardiac ischemia and myocardial infarction is obtained from a diagnose, clinical examination, radiological examination, to evaluate chest radiograph, CT scan, ultrasound, ECG, cardiac enzymes. Results. In 40 patients with SLE who conducted examination ACA IgM and IgG, obtained 3 people (7.5%) with positive IgM ACA, and 37 patients (92.5%) with IgM ACA negative, while examination with ACA IgG was not obtained in all patients. Clinical manifestations include occurrence of thrombosis found abortion to 6 people (15%), myocardial ischemia 9 people (22.5%), myocardial ischemia and abortion was found in 2 persons (5%), due to a stroke thrombosis 2 people (5%). IgM ACA levels with manifestation of thrombosis was 14.10±1.10 U/ml. From statistical tests found a significant relationship between clinical manifestations of thrombosis with IgM ACA levels (r=0362, p=0021). Conclusion. re was a significant correlation between levels of anticardiolipin antibodies with clinical manifestations of thrombosis in patients with SLE.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.772/CHR/h/041100737 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.7 Diseases of musculoskeletal system |
| Divisions: | Profesi Kedokteran > Spesialis THT Kepala dan Leher, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 30 May 2012 10:01 |
| Last Modified: | 30 May 2012 10:01 |
| URI: | http://repository.ub.ac.id/id/eprint/158401 |
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