Arif, MochMundir (2014) Kadar Reseptor Glukokortikoid α dan β pada Polip Hidung Tipe Eosinofilik dan Tipe Netrofilik. Magister thesis, Universitas Brawijaya.
Abstract
Penatalaksanaan polip hidung banyak didasarkan pada tipe histopatologinya.Polip hidung tipe eosinofilik lebih sensitif terhadap pemberian kortikosteroid sedang tipe netrofilik lebih resisten. Hasil pengobatan dengan kortikosteroid juga dipengaruhi oleh reseptor glukokortikoid. Kadar reseptor glukokortikoid β yang tinggi akan lebih resisten dibanding yang rendah. Rasio kadar reseptor glukokortikoid α dan β lebih berperan karena GR β bekerja menghambat GR α. Penelitian ini bertujuan mengetahui hubungan kadar reseptor glukokortikoid α dan β pada polip hidung tipe eosinofilik dan tipe netrofilik. Penelitian observasional analitik dengan desain cross sectional . Penelitian ini melibatkan 20 penderita polip hidung yang dilakukan biopsi atau operasi. Hasil biopsi atau operasi diperiksa jenis histopatologinya dan dihitung kadar reseptor glukokortikoid α dan β dengan pemeriksaan imunohistokimia. Data penelitian dianalisa dengan uji sampel t tidak berpasangan. Kadar reseptor glukokortikoid α pada polip hidung tipe eosinofilik didapatkan sama dengan tipe netrofilik. Kadar reseptor glukokortikoid β didapatkan lebih tinggi secara bermakna pada polip hidung tipe netrofilik dibanding tipe eosinofilik. Rasio kadar GRα/GRβ lebih tinggi pada polip hidung tipe eosinofilik dibanding tipe eosinofilik tetapi perbedaannya tidak bermakna. Kesimpulan penelitian ini kadar reseptor β lebih tinggi pada polip tipe netrofilik dengan rasio kadar GRα/GRβ lebih tinggi pada polip hidung tipe eosinofilik. Penelitian lebih lanjut diperlukan menghitung kadar reseptor glukokortikoid α dan β lebih akurat dengan menggunakan teknik ELISA (RT-PCR).
English Abstract
Management of nasal polyps is commonly based on its histopathologic type. Eosinophilic nasal polyps are more sensitive to corticosteroid administration, where as neutrophilic types are more resistant. Results of treatment with corticosteroid were also influenced by glucocorticoid receptor. Higher β Glucocorticoid Receptor (β GR) concentration render more resistency compared with lower one. Ratio of α and β GR was more meaningful because β GR acts to inhibit α GR. This study aims to determine relationship between α and β GR concentration in eosinophilic and neutrophilic nasal polyps. This is an observational analytic study with cross sectional design. This study involves 20 patients with nasal polyp who underwent biopsy or operation. biopsy or operation specimens were n evaluated for its histopathologic type. concentration of α and β GR was counted by immunohistochemistry. Data was analyzed with unpaired T-test. Concentration of α GR in eosinophilic nasal polyps was similar with neutrophilic type. Concentration of β GR in neutrophilic nasal polyps was significantly higher compared with neutrophilic type. Ratio of α GR / β GR concentration was higher in eosinophilic nasal polyps than eosinophilic, but insignificant. To conclude, β GR concentration is higher in neutrophilic nasal polyps and ratio of α GR / β GR concentration is higher in eosinophilic nasal polyps. Fur r study is required to count α GR and β GR concentration more accurately using ELISA (RT-PCR).
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.212/ARI/k/041404010 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system |
| Divisions: | Profesi Kedokteran > Spesialis THT Kepala dan Leher, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 04 Sep 2014 12:11 |
| Last Modified: | 04 Sep 2014 12:11 |
| URI: | http://repository.ub.ac.id/id/eprint/158309 |
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