Hubungan Polimorfisme Gen Il-10r1 S138g Dengan Kerentanan Terhadap Penderita Infeksi Tuberkulosis Di Rssa, Malang

Benedick, Olivia (2015) Hubungan Polimorfisme Gen Il-10r1 S138g Dengan Kerentanan Terhadap Penderita Infeksi Tuberkulosis Di Rssa, Malang. Magister thesis, Universitas Brawijaya.


Background: Indonesia is a country of 250 million population, with high burden of tuberculosis with prevalence of 183 per 100,000 population. There is considerable evidence that host genetic factors are important in determining susceptibility to mycobacterial infections. Recently, functional genetic mutations affecting IL-10 receptor 1 (IL-10R1) were described and became issue because of the important role of IL-10 as a cytokine anti-inflamatory, as if happened loss of function, in some study, increase susceptibility of tuberculosis infection. In this study, we investigated the relationship of IL-10R1 S138G loss-of-function polymorphism with susceptibility to pulmonary and extrapulmonary tuberculosis (TB) in Saiful Anwar Hospital, Malang, Indonesia. Methods: A total of 26 patients with pulmonary TB, 26 with extrapulmonary TB, and 12 control subjects were studied in case control study. Genomic DNA samples were extracted from leukocytes and used to investigate S138G polymorphism in IL-10R1 gene by multiplex allelespecific polymerase chain reaction. Results: Associations between A/G allele [odds ratio OR = 0.58; 95% confidence intervals CI = 0.11–3.04; P =0.65], GG, AG genotypes [OR=0.89; 95% CI 0.58–1.27; P=0.63] with the risk development of active pulmonary TB were found. The AA genotype was not found to be associated with resistance to extrapulmonary TB [OR=0.95; 95% CI (0.58–1.5); P=0.73]. Conclusions: No association was found between S138G SNP and pulmonary and extrapulmonary TB. Our study shows the possible role of IL-10R1 S138G loss-of-function polymorphism in Tuberculosis infection is still questionable and needed the further research. Keywords: IL-10R1 S138G polymorphism, Susceptibility Tuberculosis

Item Type: Thesis (Magister)
Identification Number: TES/614.542/BEN/h/2015/041601619
Subjects: 600 Technology (Applied sciences) > 614 Forensic medicine; incidence of injuries, wounds, disease; public preventive medicine > 614.5 Incidence of and public measure to prevent specific disease and kinds of diseases
Divisions: Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran
Depositing User: Nur Cholis
Date Deposited: 04 May 2016 09:21
Last Modified: 04 May 2016 09:21
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