Sari, AtikaWindra (2017) Pengaruh Pemberian Antioksidan Teh Hijau (Camellia Sinensis) Terhadap Kerusakan Organ Ginjal Mencit (Mus Musculus) Yang Terpapar Asap Rokok. Sarjana thesis, Universitas Brawijaya.
Abstract
Merokok merupakan salah satu penyebab terjadinya kerusakan pada organ ginjal. Pada asap rokok terdapat kandungan radikal bebas seperti tar, nikotin, dan karbonmonoksida sehingga dapat menimbulkan berbagai kerusakan pada organ ginjal antara lain kerusakan glomerulus dan tubulus ginjal. Ginjal merupakan salah satu organ penting dalam tubuh yang dapat mengeluarkan zat-zat toksik yang masuk ke dalam tubuh melalui urin. Antioksidan teh hijau diyakini mampu mengurangi kerusakan organ ginjal yang diakibatkan dari paparan asap rokok serta dapat mengikat radikal bebas. Penelitian ini dilakukan untuk menganalisis pengaruh pemberian antioksidan teh hijau (Camellia sinensis) terhadap kerusakan organ ginjal mencit yang terpapar asap rokok. Pada penelitian ini mencit (Mus musculus) dimasukkan ke dalam chamber pengasapan dan dipapar asap rokok selama 15 menit. Kemudian mencit diberi antioksidan teh hijau dengan 5 dosis berbeda. Pengasapan dan pemberian antioksidan dilakukan selama 14 hari secara berturut-turut. Setelah perlakukan selesai, dibuat preparat organ ginjal dan diamati gambaran mikroskopisnya sebanyak 5 lapang pandang setiap mencit. Hasil penelitian menunjukkan bahwa terdapat dua jenis kerusakan akibat paparan asap rokok yakni pelebaran ruang kapsula bowman pada glomerulus dan penyempitan lumen tubulus. Pemberian antioksidan teh hijau mampu mengurangi kerusakan organ ginjal hingga 20,51%.
English Abstract
Smoking is one of the activities that causes of diseases of the kidney. The cigarette smoke contains many free radicals such as tar, nicotine, and carbonmonoxide. The free radicals into the kidney then it can cause many damages of the kidney such as glomerulus and tubulus damage. Kidney is an important organs in the body, because the kidney can filter the toxic matter from the metabolism and then thrown through urine. Green tea antioxidant is believed to reduce of kidney damages that exposed by smoke of cigarette and then it can reduce reaction of free radicals. This research was conducted to analyse the effect of the green tea (Camellia sinensis) antioxidant to the mice kidney (Mus musculus) damage that exposed by smoke of cigarette. In the research, the mice was entered to the chamber then it was given cigarette smoke in there for 15 minutes. And then, the mice is given the green tea antioxidant with 5 dose varians. Smoke of cigarette and the antioxidant are conducted during 14 days. After that, the preparation of the kidney organ was made and then it was observed the image in the microscope. The result of this research are two damages of the kidney, enlargement of capsule bowman in the glomerulus and stricture of tubulus. The green tea antioxidant can reduce the kidney damages equal to 20,51%.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/MIPA/2017/179/051703521 |
| Subjects: | 500 Natural sciences and mathematics > 530 Physics |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Fisika |
| Depositing User: | Kustati |
| Date Deposited: | 28 Apr 2017 09:05 |
| Last Modified: | 28 Apr 2017 09:05 |
| URI: | http://repository.ub.ac.id/id/eprint/155222 |
Actions (login required)
 |
View Item |