Pengaruh Pemberian Ekstrak Teh Beras Hitam Sangrai Terhadap Profil Lipid Serum Darah Tikus Wistar Jantan (Rattus Norvegicus) Hiperkolesterolemia

Aisyah, Siti (2016) Pengaruh Pemberian Ekstrak Teh Beras Hitam Sangrai Terhadap Profil Lipid Serum Darah Tikus Wistar Jantan (Rattus Norvegicus) Hiperkolesterolemia. Sarjana thesis, Universitas Brawijaya.

Abstract

Hiperkolesterolemia adalah suatu kondisi yang ditandai dengan tingginya kadar kolesterol. Penyakit ini disebabkan oleh pola konsumsi makan tinggi lemak dan tidak seimbang. Berdasarkan data WHO, jumlah penderita hiperkolesterol di Indonesia mencapai 30%. Salah satu pangan fungsional yang tergolong baru yaitu minuman berbasis beras hitam sangrai yang sering disebut sebagai Teh Beras Hitam Sangrai (TBHS). Proses penyangraian, diketahui dapat meningkatkan senyawa bioaktif. Namun, penelitian yang dilakukan hanya sebatas pada uji fitokimia. Sehingga masih perlu dilakukan penelitian lebih lanjut untuk membuktikan manfaat teh beras hitam sangrai secara ilmiah dengan uji in vivo. Penelitian ini bertujuan mengetahui pengaruh ekstrak TBHS yang diekstrak dengan metode maserasi menggunakan pelarut etanol 96% yang mengandung asam sitrat 0,5%, untuk selanjutnya diuji khasiatnya pada tikus wistar jantan (Rattus norvergicus) kondisi hiperkolesterolemia. Penelitian ini menggunakan rancangan percobaan pre and post control group design, dilakukan menggunakan 30 ekor tikus usia 8 minggu. Semua hewan coba diberi perlakuan, dengan ketentuan perlakuan hiperkolesterol; kelompok positif (KP); kelompok kontrol obat simvastatin 1,03 mg/Kg BB (KO); kelompok ekstrak TBHS 100 mg/Kg BB (D1); kelompok ekstrak TBHS 200 mg/Kg BB (D2); dan perlakuan keadaan normal (KN). Pengkondisian hiperkolesterol menggunakan diet pakan tinggi kolesterol. Pengujian profil lipid serum darah diukur sebelum diberi perlakuan (Pre-Test) dan sesudah diberi perlakuan (Post- Test). Berdasarkan hasil penelitian, diketahui bahwa perlakuan ekstrak TBHS pada dosis 100 mg/Kg BB ; secara signifikan menurunkan kadar kolesterol total sebesar 23,1%, dan kadar LDL sebesar 64,1%; secara signifikan menaikkan kadar HDL sebesar 38,75%; dan secara tidak signifikan menurunkan kadar trigliserida sebesar 30,9%; Adapun perlakuan ekstrak TBHS pada dosis 200 mg/Kg; secara signifikan menurunkan kadar kolesterol total sebesar 16,25%, kadar trigliserida sebesar 52,41% dan kadar LDL sebesar 39,88%; dan secara tidak signifikan menaikkan kadar HDL sebesar 33,81%. Kesimpulan dari penelitian ini menunjukkan bahwa pemberian ekstrak TBHS, mampu memperbaiki profil lipid serum darah tikus wistar jantan kondisi hiperkolesterolemia. Namun, pemberian ekstrak TBHS dosis 100 mg/Kg BB mempunyai persentase lebih besar dalam memperbaiki kadar profil lipid serum darah tikus wistar jantan dibandingkan perlakuan ekstrak TBHS dosis 200 mg/Kg BB.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FTP/2016/287/051605891
Subjects: 300 Social sciences > 338 Production > 338.1 Agriculture
Divisions: Fakultas Teknologi Pertanian > Teknologi Hasil Pertanian
Depositing User: Nur Cholis
Date Deposited: 28 Sep 2016 13:44
Last Modified: 24 Oct 2021 13:08
URI: http://repository.ub.ac.id/id/eprint/150835
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