Efek Terapi Yogurt Susu Kambing Terhadap Kadar Malondialdehyde (Mda) Dan Gambaran Histopatologi Pembuluh Darah Tikus (Rattus Norvegicus) Model Hipertensi Yang Diinduksi Deoxycorticosterone Acetate (D

Alfisa, Ayu (2016) Efek Terapi Yogurt Susu Kambing Terhadap Kadar Malondialdehyde (Mda) Dan Gambaran Histopatologi Pembuluh Darah Tikus (Rattus Norvegicus) Model Hipertensi Yang Diinduksi Deoxycorticosterone Acetate (D. Sarjana thesis, Universitas Brawijaya.

Abstract

Hipertensi merupakan salah satu penyakit kardiovaskular yang banyak menyebabkan kematian di dunia. Hipertensi adalah kondisi dimana terjadi peningkatan tekanan darah secara kronis. Pengobatan hipertensi seperti pemberian obat-obatan yang bersifat angiotensin converting enzyme (ACE)-inhibitor dalam jangka panjang akan menimbulkan efek samping. Yogurt susu kambing mengandung peptida bioaktif yang memiliki aktivitas ACE-inhibitor dan antioksidan yang diharapkan dapat digunakan sebagai antihipertensi. Penelitian ini bertujuan untuk mengetahui efek terapi yogurt susu kambing terhadap kadar malondyaldehide (MDA) dan gambaran histopatologi pembuluh darah tikus model hipertensi hasil induksi deoxycorticosterone acetate (DOCA)-salt. Kadar MDA pembuluh darah dianalisis menggunakan metode Thiobarbaturic Acid (TBA) dan preparat histopatologi pembuluh darah dengan metode pewarnaan Hematoksilin-Eosin (HE). Penelitian ini menggunakan tikus wistar jantan yang terbagi menjadi 5 kelompok perlakuan yaitu kelompok normal, kelompok hipertensi, kelompok terapi Captopril 5 mg/kg BB, kelompok terapi yogurt susu kambing 300 mg/kg BB dan kelompok terapi yogurt susu kambing 600 mg/kg BB. Hasil penelitian menunjukkan kadar MDA kelompok tikus hipertensi berbeda (p<0,05) dibandingkan kelompok normal. Kadar MDA kelompok terapi yogurt susu kambing 300 mg/kg BB tidak berbeda nyata dibandingkan kelompok terapi yogurt susu kambing 600 mg/kg BB dan kelompok terapi Captopril 5 mg/kg BB. Gambaran histopatologi pembuluh darah menunjukkan perbaikan berupa penurunan proliferasi sel otot polos pembuluh darah tikus yang diterapi yogurt susu kambing. Dari hasil penelitian dapat disimpulkan bahwa terapi yogurt susu kambing dapat menurunkan kadar MDA dan memperbaiki gambaran histopatologi pembuluh darah.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FKH/2016/98/051610806
Subjects: 600 Technology (Applied sciences) > 636 Animal husbandry > 636.08 Specific topics in animal husbandry > 636.089 Veterinary medicine
Divisions: Fakultas Kedokteran Hewan > Kedokteran Hewan
Depositing User: Nur Cholis
Date Deposited: 07 Nov 2016 13:24
Last Modified: 20 Oct 2021 03:25
URI: http://repository.ub.ac.id/id/eprint/127246
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