Pengaruh Modifikasi Polimer Guar Gum Suksinat Sebagai Pengontrol Pelepasan Terhadap Profil Pelepasan Tablet Ibuprofen Tertarget Kolon

Christianto, Andre (2017) Pengaruh Modifikasi Polimer Guar Gum Suksinat Sebagai Pengontrol Pelepasan Terhadap Profil Pelepasan Tablet Ibuprofen Tertarget Kolon. Sarjana thesis, Universitas Brawijaya.

Abstract

Colon Targeting Drug Delivery System adalah salah satu pendekatan untuk meningkatkan jumlah obat yang terlokalisir pada kolon untuk terapi Inflammatory Bowel Disease. Guar gum adalah salah satu polimer polisakarida yang memiliki sifat sangat viscous dan sangat mudah mengembang dengan adanya air. Crosslinking guar gum perlu dilakukan untuk mengubah sifat dari polimer ini menjadi polimer yang sensitif terhadap pH 7,4 sehingga mampu menghambat pelepasan obat sebelum mencapai kolon. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh modifikasi guar gum dengan crosslinking serta pembuatan mikropartikel terhadap pelepasan obat yang tertarget kolon. Penelitian dilakukan dengan membuat 3 formula dengan polimer yang berbeda yaitu guar gum sebagai matriks, guar gum suksinat sebagai matriks, dan mikropartikel guar gum suksinat. Hasil penjeratan obat menunjukkan hasil 98,913 ± 0,312%. Hasil tertinggi dari profil pelepasan obat 2 jam dan 5 jam adalah mikropartikel guar gum suksinat dengan adanya perbedaan bermakna dari setiap formula. Hasil tertinggi dari profil pelepasan obat 9 jam menunjukkan tablet guar gum suksinat sebagai matriks adalah tablet dengan guar gum suksinat sebagai matriks dengan hasil analisis statistik menunjukkkan pembuatan crosslinked dibanding mikropartikel tidak ada perbedaan yang bermakna. Kesimpulan pada penelitian ini yaitu profil pelepasan ibuprofen dalam medium basa yang paling baik adalah tablet dengan matriks guar gum suksinat, sedangkan pada medium pH 1,2 yang paling baik adalah tablet dengan guar gum tanpa modifikasi sebagai matriks, dan formula yang paling optimum adalah tablet dengan matriks guar gum suksinat.

English Abstract

Colon Targeting Drug Delivery System is one of the approaches to increase the amount of drug that is localized to the colon for the treatment of Inflammatory Bowel Disease. Guar gum is a polysaccharide polymer which has very viscous properties and very easy to swell with the presence of water. Guar gum crosslinking needs to change the properties of these polymers into polymer that is sensitive to pH 7,4 so it can inhibit the drug release before it reaches colon. The purpose of this study is to determine the influence of guar gum modification with crosslinking and microparticles on colon targeted drug release. Research carried out by making three formula with different polymers which are guar gum matrix, succinic guar gum matrix, and succinic guar gum microparticles. The results of the drug entrapment showed the results of 98.913 ± 0.312%. The test results showed the highest release profile of 2 hours and 5 hours is succinic guar gum microparticles tablets with significant differences from each formula. The results showed the highest 9 hours drug release profile is tablet with succinic guar gum as a matrix with statistical analysis indicate that manufacture of crosslinked than microparticles was no significant difference. Conclusions on this research that the best drug release profile in alkaline medium is tablet with succinic guar gum as a matrix, while in the pH 1,2 medium is tablet with guar gum matrix without modification, and the most optimum formula is tablet with succinic guar gum as a matrix.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2017/77/051703306
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Kustati
Date Deposited: 13 Apr 2017 14:06
Last Modified: 19 Oct 2021 02:28
URI: http://repository.ub.ac.id/id/eprint/126738
[thumbnail of 9._BAB_6.pdf] Text
9._BAB_6.pdf

Download (1MB)
[thumbnail of 8._BAB_5.pdf] Text
8._BAB_5.pdf

Download (2MB)
[thumbnail of 12._Lampiran.pdf] Text
12._Lampiran.pdf

Download (5MB)
[thumbnail of 11._Daftar_Pustaka.pdf] Text
11._Daftar_Pustaka.pdf

Download (2MB)
[thumbnail of 10._BAB_7.pdf] Text
10._BAB_7.pdf

Download (1MB)
[thumbnail of 2._Lembar_Pengesahan.pdf] Text
2._Lembar_Pengesahan.pdf

Download (1MB)
[thumbnail of 3._Abstrak_Indonesia_+_Inggris.pdf] Text
3._Abstrak_Indonesia_+_Inggris.pdf

Download (1MB)
[thumbnail of 5._BAB_2.pdf] Text
5._BAB_2.pdf

Download (2MB)
[thumbnail of 4._BAB_1.pdf] Text
4._BAB_1.pdf

Download (1MB)
[thumbnail of 6._BAB_3.pdf] Text
6._BAB_3.pdf

Download (1MB)
[thumbnail of 1._Cover_+_Daftar_Isi.pdf] Text
1._Cover_+_Daftar_Isi.pdf

Download (2MB)
[thumbnail of 7._BAB_4.pdf] Text
7._BAB_4.pdf

Download (2MB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (35kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (14kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (36kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (15kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (32kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (14kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (3kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (27kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (11kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (3kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (48kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (19kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (33kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (13kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (3kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (44kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (18kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (40kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (16kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (40kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (17kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (43kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (18kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (46kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (17kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (35kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (15kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)

Actions (login required)

View Item View Item