Rosalina, Ahadiya (2016) Efek Pemberian Minyak Kelapa Sawit dalam Mikrosfer Kitosan terhadap Kadar Colony Stimulating Factor 1 pada Kondisi Nekrosis Tubular Akut secara In Vivo. Sarjana thesis, Universitas Brawijaya.
Abstract
NTA (Nekrosis Tubular Akut) merupakan gangguan pada sel tubulus ginjal yang terjadi baik akibat iskemi maupun paparan nefrotoksin yang menyebabkan kerusakan sel tubulus ginjal sehingga dapat mengakibatkan GGA (Gagal Ginjal Akut). Penelitian sebelumnya menunjukkan bahwa kadar CSF-1 yang tinggi menghasilkan perbaikan sel yang lebih baik di ginjal yang mengalami iskemi. Salah satu agen yang berasal dari bahan alam dan dapat digunakan sebagai terapi NTA adalah minyak kelapa sawit (CPO) yang mengandung senyawa tokols. CPO dalam bentuk mikrosfer kitosan BMR mampu menyebabkan akumulasi CPO di ginjal untuk mengoptimalkan efek terapi sehingga dapat meningkatkan kadar CSF-1 dan memicu perbaikan NTA. Studi posttest experimental dengan controlled group design dilakukan pada 24 Mus musculus. Sampel dibagi menjadi 6 kelompok, yaitu kontrol positif dengan NTA (KP), kontrol negatif tanpa NTA (KN), kelompok NTA + CPO dosis 0,071 mg/gBB dalam mikrosfer kitosan (P1), kelompok NTA + CPO dosis 0,107 mg/gBB dalam mikrosfer kitosan (P2), kelompok NTA + CPO dosis 0,140 mg/gBB (P3), dan kelompok NTA + CPO dosis 0,210 mg/gBB (P4). Variabel yang diukur adalah kadar CSF-1 menggunakan metode spektrofotometri dengan prinsip enzimatis Elisa. Hasil yang diperoleh menunjukkan nilai CSF-1 dari tinggi ke rendah secara berturut-turut adalah P3 yaitu 0,300 ± 0,103 ng/L; KN dengan nilai tengah 0,255 ng/L; P1 yaitu 0,220 ± 0,076 ng/L; P2 yaitu 0,180 ± 0,104 ng/L; P4 yaitu 0,120 ± 0,090 ng/L; dan KP yaitu 0,080 ± 0,033 ng/L dimana terdapat perbedaan yang bermakna antara KP dengan KN, P1, dan P3 dengan nilai signifikansi (p < 0,05). Sehingga dapat disimpulkan bahwa CPO dengan dosis 0,071 mg/gBB dalam mikrosfer kitosan mampu meningkatkan kadar CSF-1 ginjal secara signifikan pada kondisi NTA.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2017/17/051700644 |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 03 Feb 2017 08:28 |
| Last Modified: | 19 Oct 2021 07:00 |
| URI: | http://repository.ub.ac.id/id/eprint/126662 |
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