Efek Pemberian Mikrosfer Kitosan Minyak Kelapa Sawit terhadap Jumlah Sel Tubulus Proksimal Ginjal Mencit dengan Nekrosis Tubular Akut

Hapsari, TiaraDimas (2016) Efek Pemberian Mikrosfer Kitosan Minyak Kelapa Sawit terhadap Jumlah Sel Tubulus Proksimal Ginjal Mencit dengan Nekrosis Tubular Akut. Sarjana thesis, Universitas Brawijaya.

Abstract

Nekrosis Tubular Akut (NTA) merupakan penyebab utama Gagal Ginjal Akut (GGA), yang ditandai dengan adanya kerusakan dan kematian sel epitel tubulus. Salah satu bahan alam yang dapat dimanfaatkan dalam terapi ini adalah minyak kelapa sawit. Kandungan senyawa tocols dalam minyak kelapa sawit memiliki aktivitas antioksidan yang potensial. Formulasi minyak kelapa sawit dengan kitosan berat molekul rendah dalam bentuk mikrosfer dapat meningkatkan distribusi zat aktif di ginjal sehingga dapat memberikan efek terapi yang lebih baik dengan efek samping yang minimal. Penelitian ini bertujuan untuk mengetahui efek pemberian mikrosfer kitosan minyak kelapa sawit terhadap jumlah kerusakan sel tubulus proksimal ginjal mencit dengan NTA. Studi eksperimental menggunakan experimental post test control group design pada 24 Mus musculus. Sampel dibagi menjadi 6 kelompok yaitu kontrol positif (KP), kontrol negatif (KN), bobot mikrosfer kitosan minyak kelapa sawit 0,14 mg/gBB (dosis minyak kelapa sawit 0,0715 mg/gBB) (P1), bobot mikrosfer kitosan minyak kelapa sawit 0,21 mg/gBB (dosis minyak kelapa sawit 0,107 mg/gBB) (P2), minyak kelapa sawit dosis 0,14 mg/gBB (P3), dan minyak kelapa sawit dosis 0,21 mg/gBB (P4). Variabel yang diukur adalah jumlah kerusakan sel epitel tubulus proksimal dengan pewarnaan Hematoksilin-Eosin (HE) yang diamati dengan mikroskop cahaya. Hasil menunjukkan bahwa terdapat perbedaan signifikan (p<0,001) terhadap jumlah kerusakan sel tubulus proksimal ginjal pada kelompok yang mendapatkan terapi (P1, P2, P3, dan P4), dengan bobot optimal mikrosfer kitosan minyak kelapa sawit adalah 0,21 mg/gBB (kelompok P2) dan dosis optimal minyak kelapa sawit adalah 0,14 mg/gBB (kelompok P3). Kesimpulan dari penelitian ini adalah pemberian mikrosfer kitosan minyak kelapa sawit memiliki efek terhadap jumlah sel tubulus proksimal ginjal mencit dengan NTA

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2017/16/051700643
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 03 Feb 2017 08:23
Last Modified: 19 Oct 2021 06:59
URI: http://repository.ub.ac.id/id/eprint/126655
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