Pengaruh Perbandingan Polimer Matriks HPMC dan Kitosan terhadap Karakteristik Sediaan Patch Fitosom Ekstrak Tebu (Saccharum officinarum)

Mugni, AkbarRozaaq (2016) Pengaruh Perbandingan Polimer Matriks HPMC dan Kitosan terhadap Karakteristik Sediaan Patch Fitosom Ekstrak Tebu (Saccharum officinarum). Sarjana thesis, Universitas Brawijaya.

Abstract

Diabetes Mellitus (DM) disebabkan oleh ketidakmampuan tubuh dalam memproduksi atau tidak efektifnya penggunaan hormon insulin sehingga terjadi peningkatan kadar gula darah dalam tubuh. DM tidak dapat disembuhkan, akan tetapi terapinya dilakukan secara kontinyu sehingga dapat mempengaruhi kepatuhan pasien. Tanaman tebu (Saccharum officinarum) merupakan tanaman penghasil gula yang dapat memicu terjadi DM, namun kandungan sakarin dalam tebu justru memiliki potensi sebagai agen antidiabetes. Tebu dapat dikembangkan menjadi sediaan patch untuk terapi DM yang dapat meningkatkan kepatuhan pasien. Penelitian ini melakukan formulasi pembuatan patch menggunakan bahan dasar fitosom ekstrak tebu dengan tiga formula perbandingan polimer, meliputi: PI (HPMC 2 gram), PII (HPMC 1 gram dan Kitosan 1 gram), serta PIII (Kitosan 2 gram). Ekstraksi dilakukan menggunakan metode digesti dengan pelarut etanol 50% dan menghasilkan rendemen 26,12% ekstrak tebu yang positif mengandung sakarin. Ekstrak tebu di formulasikan menjadi fitosom dalam sediaan patch dengan metode solvent evaporation. Hasil yang didapat yaitu perbandingan polimer matriks mempengaruhi karakteristik fisik patch yang meliputi organoleptis, daya lipat, dan keseragaman bobot. Formula optimum adalah formula dengan perbandingan polimer HPMC dan kitosan 1:1 dengan karakteristik fisik berwarna coklat, bau khas tebu, serta bentuk yang halus dan lentur. Daya lipat yang dimiliki lebih dari 200x. Bobot film sebesar 5,66 g ± 0,02 dan ketebalan 0,40 mm ± 0,01. Formula optimum patch tidak menimbulkan iritasi atau udem pada kulit kelinci.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2016/798/051700751
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 02 Feb 2017 09:24
Last Modified: 19 Oct 2021 04:18
URI: http://repository.ub.ac.id/id/eprint/126512
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