Pengaruh Konsentrasi Pektin Sebagai Matriks Terhadap Profil Pelepasan Obat Kapsul Floating Drug Delivery System Effervescent Ranitidin.

Pinanda, Ayuh (2016) Pengaruh Konsentrasi Pektin Sebagai Matriks Terhadap Profil Pelepasan Obat Kapsul Floating Drug Delivery System Effervescent Ranitidin. Sarjana thesis, Universitas Brawijaya.

Abstract

Ranitidin merupakan antagonis reseptor H2 yang diabsorbasi sama baiknya di dalam lambung maupun di dalam usus halus serta dimetabolisme di dalam kolon. Salah satu fungsi ranitidin adalah untuk mengatasi erosif esofagitis dengan dosis terapi efektif 150 mg empat kali sehari, sedangkan pemberian dosis alternatif 300 mg dapat mengakibatkan fluktuasi kadar obat di dalam darah, sehingga ranitidin ini merupakan kandidat yang sesuai untuk dikembangkan menjadi bentuk sediaan FDDS dengan target pelepasan hingga 12 jam agar dapat digunakan cukup 2 kali sehari. Floating drug delivery system (FDDS) merupakan sistem penghantaran lepas lambat yang bekerja dengan cara membuat sediaan terapung di dalam lambung pada kurun waktu yang cukup lama tanpa mempengaruhi pengosongan lambung. Pektin berhasil memperpanjang pelepasan banyak obat dengan terbentuknya larutan viskos dan gel secara cepat ketika kontak dengan air, oleh karena itu pektin sesuai untuk dijadikan matriks dalam sediaan kapsul FDDS. Namun dikarenakan kemampuan mengembang pektin yang tidak terlalu tinggi maka perlu dibuat dalam bentuk effervescent. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi pektin terhadap profil pelepasan obat kapsul FDDS effervescent ranitidin. Konsentrasi pektin yang digunakan adalah 27,5% dan 32,5%. Hasil uji pelepasan obat menunjukkan bahwa pada konsentrasi pektin 27,5% dapat menunda pelepasan hingga 4 jam, sedangkan konsentrasi 32,5% dapat menunda pelepasan hingga 6 jam. Kesimpulan dari penelitian ini adalah semakin besar konsentrasi pektin yang ditambahkan menyebabkan pelepasan ranitidin menjadi semakin tertunda secara signifikan walaupun masih belum memenuhi spesifikasi.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2016/615/051610659
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 22 Nov 2016 08:25
Last Modified: 19 Oct 2021 02:23
URI: http://repository.ub.ac.id/id/eprint/126328
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