Dharmesta, NayaAdi (2016) Efek Darapladib Terhadap Perubahan Kadar Oxidized LDL (Ox-LDL) Pada Tikus Sprague Dawley Model Diabetes Mellitus Tipe 2. Sarjana thesis, Universitas Brawijaya.
Abstract
Penyakit kardiovaskuler, terutama penyakit jantung koroner, menempati peringkat pertama penyebab kematian di dunia dengan angka kematian sebesar 29,34% dari seluruh penyebab kematian. Aterosklerosis adalah suatu penyakit inflamasi kronis yang ditandai dengan akumulasi dari sel inflamasi, sel otot polos, lipid, dan jaringan ikat pada tunika intima. Resistensi insulin merupakan faktor risiko terjadinya aterosklerosis yang didapatkan pada keadaan DM tipe 2. Penyebab terjadinya aterosklerosis sangat kompleks namun salah satu penyebab yang saat ini ditemukan adalah akibat enzim Lp-pLA2 sebagai inisiator terjadinya progresivitas aterosklerosis. Lp-pLA2 adalah enzim yang memecah Ox-LDL menjadi produk pro-aterosklerosis. Saat ini ditemukan pilihan terapi terbaru melalui inhibisi enzim Lp-pLA2 menggunakan Darapladib. Penelitian eksperimental ini bertujuan untuk mengetahui efek Darapladib terhadap kadar Ox-LDL plasma pada tikus Sprague-Dawley model Diabetes Mellitus tipe 2. Penelitian ini menggunakan 30 ekor tikus Sprague-Dawley jantan yang dibagi dalam tiga kelompok: (1) kelompok normal; (2) kelompok model DM tipe 2; dan (3) kelompok model DM tipe 2 dengan pemberian darapladib (20mg/kgBB). masing-masing kelompok dibagi menjadi dua kelompok lagi berdasarkan serial waktu 8 minggu dan 16 minggu. Parameter yang diukur adalah kadar Ox-LDL plasma. Parameter pendukung yang diukur dalam penelitian ini adalah kadar insulin plasma, resistensi insulin, dan profil lipid (kolesterol total, LDL, dan HDL). Pengukuran kadar Ox-LDL plasma dilakukan dengan menggunakan ELISA. Rata-rata kadar Ox-LDL plasma pada kelompok DM tipe 2 dan darapladib pada serial waktu 8 minggu dan 16 minggu masing-masing adalah 0,991 ng/mL dan 1,948 ng/mL. Angka ini lebih rendah daripada rata-rata pada kelompok model DM tipe 2 pada serial waktu 8 minggu dan 16 minggu, yaitu 4,622 ng/mL dan 5,920 ng/mL. Uji One-Way ANOVA menunjukkan perbedaan yang bermakna dalam menurunkan kadar Ox-LDL plasma (p<0,001). Dibutuhkan suatu penelitian lebih lanjut untuk mengetahui efek samping dan dosis optimum dari pemberian darapladib.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2016/325/051605117 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 06 Jun 2016 10:43 |
| Last Modified: | 21 Oct 2021 02:04 |
| URI: | http://repository.ub.ac.id/id/eprint/126007 |
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