Pembandingan Koefisien Partisi (log P) dan Kelarutan dalam Air dari Senyawa Timokuinon dan Turunannya (2-(4-bromobutil)sikloheksa-2,5-dien-1,4-dion).

Putri, DarizkiSilviana (2016) Pembandingan Koefisien Partisi (log P) dan Kelarutan dalam Air dari Senyawa Timokuinon dan Turunannya (2-(4-bromobutil)sikloheksa-2,5-dien-1,4-dion). Sarjana thesis, Universitas Brawijaya.

Abstract

Struktur kimia suatu senyawa obat dapat memberi pengaruh pada profil farmakokinetika obat tersebut di dalam tubuh. Modifikasi struktur dilakukan untuk memperbaiki sifat fisika kimia senyawa obat yang kurang menguntungkan dan memudahkan suatu obat mencapai target tertentu. Penelitian ini bertujuan memberikan data fisika kimia senyawa obat secara praktis untuk pengembangan obat. Penelitian untuk sintesis senyawa turunan Timokuinon dilakukan dengan melakukan modifikasi struktur pada senyawa awal Hidrokuinon dengan penambahan rantai alifatik yang terdiri dari 4 atom C dan 1 atom Br pada atom C ke 2 cincin para-benzokuinon. Koefisien partisi (log P) senyawa Timokuinon dan senyawa turunan Timokuinon (2-(4-bromobutil)sikloheksa-2,5-dien-1,4-dion) ditentukan dengan melarutkan senyawa dalam fase oktanol/buffer berair pH 7,4 menggunakan metode shake-flask, sedangkan kelarutan dalam air dari kedua senyawa ditentukan dengan pelarutan senyawa pada buffer Britton-Robinson menggunakan metode shake-flask. Penentuan kadar dalam larutan sampel diukur menggunakan Spektrofotometer UV-Vis. Hasil penelitian ini menunjukkan bahwa koefisien partisi turunan Timokuinon lebih besar dan kelarutan dalam air lebih kecil secara signifikan dibandingkan senyawa Timokuinon. Nilai rerata log P pada senyawa (2-(4-bromobutil)sikloheksa-2,5-dien-1,4-dion) sebesar 1,250 ± 0,005 dan pada senyawa Timokuinon sebesar 1,079 (signifikansi: p = 0,002). Nilai rerata kelarutan dalam air senyawa turunan Timokuinon sebesar 4,204 ± 0,120 mg/ml, sedangkan pada Timokuinon sebesar 7,204 mg/ml (signifikansi: p < 0,001). Oleh karena itu, dapat disimpulkan bahwa dengan modifikasi struktur dihasilkan senyawa turunan Timokuinon yang memiliki lipofilisitas lebih tinggi dan kelarutan dalam air yang lebih rendah secara signifikan dibandingkan dengan senyawa Timokuinon.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2016/232/051604011
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 23 Jun 2016 08:37
Last Modified: 21 Oct 2021 00:54
URI: http://repository.ub.ac.id/id/eprint/125903
[thumbnail of BAB_3.pdf] Text
BAB_3.pdf

Download (1MB)
[thumbnail of BAB_1.pdf] Text
BAB_1.pdf

Download (1MB)
[thumbnail of BAB_2.pdf] Text
BAB_2.pdf

Download (2MB)
[thumbnail of Cover_TA_dan_Daftar_Isi.pdf] Text
Cover_TA_dan_Daftar_Isi.pdf

Download (1MB)
[thumbnail of BAB_7.pdf] Text
BAB_7.pdf

Download (1MB)
[thumbnail of DAFTAR_PUSTAKA.pdf] Text
DAFTAR_PUSTAKA.pdf

Download (1MB)
[thumbnail of BAB_4.pdf] Text
BAB_4.pdf

Download (2MB)
[thumbnail of Lembar_Pengesahan.pdf] Text
Lembar_Pengesahan.pdf

Download (2MB)
[thumbnail of BAB_5.pdf] Text
BAB_5.pdf

Download (2MB)
[thumbnail of ABSTRAK_Indonesia_dan_Inggris.pdf] Text
ABSTRAK_Indonesia_dan_Inggris.pdf

Download (1MB)
[thumbnail of BAB_6.pdf] Text
BAB_6.pdf

Download (1MB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (25kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (11kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (3kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (40kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (16kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (42kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (16kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (38kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (16kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (38kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (15kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (40kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (16kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (45kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (17kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (34kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (14kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (3kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (40kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (16kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (32kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (13kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (4kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (34kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (14kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (3kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (1kB)

Actions (login required)

View Item View Item