Pengaruh Ekstrak Spons Laut Aaptos Suberitoides Dengan Metode Maserasi 5 Hari Terhadap Proliferasi Sel Hela

Fahdi, AlifiaMarita (2016) Pengaruh Ekstrak Spons Laut Aaptos Suberitoides Dengan Metode Maserasi 5 Hari Terhadap Proliferasi Sel Hela. Sarjana thesis, Universitas Brawijaya.

Abstract

Spons Laut Aaptos Suberitoides Mengandung Senyawa Aaptamin Yang Dipercaya Berfungsi Sebagai Antikanker. Spons Ini Sangat Potensial Dikembangkan Kasrena Sangat Melimpah Pada Habitatnya Yitu Pada Daerah Asia Tenggara Khususnya Di Indonesia. Peneitian Ini Bertujuan Untuk Mengetahui Pengaruh Ekstrak Spons Laut Aaptos Suberitoides Terhadap Proliferasi Sel Hela Sebagai Model In Vitro Dari Sel Kanker Serviks. Metode Yang Digunakan Adalah True Eksperimental Design Dengan Dosis Ekstrak 33,5 Μg/Ml, 67 Μg/Ml, 134 Μg/Ml, Dan 268 Μg/Ml Dengan Kontrol Se Tanpa Perlakuan Dan Baku Standar Cisplatin 16,8 Μg/Ml Sebagai Pembanding. Ekstraksi Yang Digunakan Yaitu Dengan Metode Maserasi Selama 5 Hari Menggunakan Pelarut Etanol 96%. Hasil Yang Diperoleh Pada Semua Dosis Ekstrak Yang Digunakan Dapat Menghambat Proliferasi Sangat Signifikan Dengan P = 0,000. Dosis IC50 Ekstrak Aaptos Suberitoides Yang Didapatkan Sebesar 57,43 Μg/Ml .Ekstrak 134 Μg/Ml Mampu Menghambat Proliferasi Sebanyak 93% Yang Ekuivalen Dengan Hambatan Proliferasi Cisplatin 16,8 Μg/Ml.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2016/147/051502569
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 30 Mar 2016 14:11
Last Modified: 20 Oct 2021 07:36
URI: http://repository.ub.ac.id/id/eprint/125807
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