Efek Supernatan Yogurt LBA-ST sebagi Antikanker pada Sel HeLa Melalui Hambatan Ekspresi Laminin5-γ2 In-vitro

Ridho, Wildan Mochamad (2016) Efek Supernatan Yogurt LBA-ST sebagi Antikanker pada Sel HeLa Melalui Hambatan Ekspresi Laminin5-γ2 In-vitro. Sarjana thesis, Universitas Brawijaya.

Abstract

Laminin5-γ2 merupakan protein marker dalam perkembangan sel kanker terutama pada penderita kanker serviks. Ekspresi Laminin5-γ2 yang berlebihan akan menyebabkan peningkatan proses invasi, migrasi dan adhesi sel kanker. Hal tersebut yang menyebabkan terjadinya proses metastasis sel-sel kanker serviks. Yoghurt adalah produk probiotik yang diperoleh dari fermentasi susu menggunakan bakteri asam laktat yaitu yaitu Lactobacilus bulgaricus dan Streptococcus thermophilus (LBA-ST). Supernatan yogurt LBA-ST mempunyai kandungan metabolit terbesar berupa SCFA (Short Chain Fatty Acids) meliputi propionat, butirat, dan asetat serta mempunyai efek antikanker via modulasi system imun dan antimutagenik. Tujuan penelitian ini untuk mengetahui dosis efektif (ED) Supernatan Yogurt LBA-ST (Lactobacillus Bulgaricus dan Streptococcus Thermopilus) yang dapat menurunkan aktivitas Laminin5-γ2 terhadap terapi sel HeLa (sel line kanker serviks). Pengujian aktivitas ekspresi Laminin5-γ2 pada sel HeLa yang telah dipapar dengan supernatan yogurt menggunakan metode imunositokimia. Data yang telah didapat dari penelitian diolah dengan uji statistik meliputi uji normalitas, uji homogenitas dan uji One-way ANOVA. Dari hasil penelitian didapatkan bahwa supernatan yogurt dapat menurunkan ekspresi dari Laminin5-γ2 dengan dosis efektif yang didapat sebesar 40% v/v (p<0,05±0,005).

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2016/145/051502567
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 30 Mar 2016 14:04
Last Modified: 23 Nov 2021 02:51
URI: http://repository.ub.ac.id/id/eprint/125805
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