Optimasi Fast Disintegrating Tablet Fitosom Ekstrak Pegagan (Centella Asiatica L.) Menggunakan Metode Simplex Lattice Design

Purmitasari, Erlin Aditia (2016) Optimasi Fast Disintegrating Tablet Fitosom Ekstrak Pegagan (Centella Asiatica L.) Menggunakan Metode Simplex Lattice Design. Sarjana thesis, Universitas Brawijaya.

Abstract

Asiatikosida Merupakan Senyawa Marker Dalam Tanaman Pegagan (Centella Asiatica) Yang Mempunyai Khasiat Terutama Sebagai Antiinflamasi. Asiatikosida Bersifat Hidrofil Dengan Molekul Yang Besar Sehingga Penetrasi Menembus Membran Sel Lebih Sulit. Oleh Karena Itu Diperlukan Modifikasi Kepolaran Asiatikosida Melalui Sistem Penghantaran Obat Yaitu Fitosom. Untuk Memudahkan Pemberian Fitosom Pada Pasien Geriatri Dan Pediatri Yang Susah Menelan Obat Maka Diperlukan Bentuk Sediaan Yang Sesuai Yaitu Fast Disintegrating Tablet. Fast Disintegrating Tablet Merupakan Tablet Yang Akan Hancur Dalam Rongga Mulut Dengan Cepat. Penelitian Ini Bertujuan Untuk Mengetahui Pengaruh Dan Perbandingan Kadar Microcrystalline Cellulose Dan Sodium Starch Glycolate Dalam Menghasilkan Sifat Fisik Fast Disintegrating Tablet Yang Optimum. Optimasi Formula Fast Disintegrating Tablet Fitosom Ekstrak Pegagan Dilakukan Menggunakan Metode Simplex Lattice Design (Sld) Dengan 3 Formula Yaitu Formula A (Microcrystalline Cellulose 100%), Formula B (Microcrystalline Cellulose 50% Dan Sodium Starch Glycolate 50%), Dan Formula C (Sodium Starch Glycolate 50%). Dari Hasil Penelitian Diperoleh Formula Optimum Pada Kombinasi Microcrystallin Cellulose 60% Dan Sodium Starch Glycolate 40%. Semakin Tinggi Kadar Microcrystalline Cellulose Yang Digunakan Semakin Tinggi Respon Kekerasan, Waktu Keterbasahan, Dan Waktu Disintegrasi Sedangkan Semakin Tinggi Kadar Sodium Starch Glycolate Yang Digunakan Semakin Tinggi Respon Kerapuhan Tablet, Dan Disolusi Fast Disintegrating Tablet Fitosom Ekstrak Pegagan.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2016/144/051502566
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 30 Mar 2016 13:12
Last Modified: 23 Nov 2021 02:50
URI: http://repository.ub.ac.id/id/eprint/125804
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