Efek Ekstrak Spons Laut (Aaptos Suberitoides) Pada Apoptosis Sel Hela Melalui Ekspresi Caspase 3

Dhiniansa, NadyaPutsa (2016) Efek Ekstrak Spons Laut (Aaptos Suberitoides) Pada Apoptosis Sel Hela Melalui Ekspresi Caspase 3. Sarjana thesis, Universitas Brawijaya.

Abstract

.Spons Laut Aaptos Suberitoides Mengandung Aaptamine, Demethyloxyaaptamine Dan Isoaaptamine, Yang Merupakan Senyawa Alkaloid, Yang Dipercaya Sebagai Antikanker. Penelitian Ini Bertujuan Untuk Mengetahui Pengaruh Ekstrak Spons Laut Aaptos Suberitoides Terhadap Ekspresi Caspase 3 Secara In Vitro Menggunakan True Experimental Design, Post Test Only, Dan Control Group Design Dilakukan Terhadap Model Sel Kanker Serviks Yaitu Sel Hela. Sel Hela Dibagi Menjadi 3 Kelompok. Kelompok Pertama Yakni Diberi Perlakuan Dengan Dosis Ekstrak 67 Μg/Ml. Sedangkan 2 Kelompok Lainnya Adalah Kelompok Kontrol Dengan Tanpa Perlakuan Sebagai Kontrol Negatif Dan Cisplatin Dengan Dosis 16,8 Μg/Ml Sebagai Kontrol Positif. Untuk Melihat Ekspresi Caspase 3 Menggunakan Metode Imunositokimia. Hasil Penelitian Menunjukkan Bahwa Terjadi Peningkatan Ekspresi Caspase 3 Akibat Ekstrak Spons Yang Ditunjukkan Dengan Nilai Indeks Ekspresi Caspase 3 Sebesar 0,09 Sedangkan Cisplatin Dan Kontrol Masing-Masing Sebesar 0,932, Dan 0. Kesimpulan Dari Penelitian Ini Adalah Ekstrak Spons Laut Aaptos Suberitoides Mampu Meningkatkan Ekspresi Caspase 3

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2015/901/051602552
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 30 Mar 2016 12:56
Last Modified: 20 Oct 2021 06:24
URI: http://repository.ub.ac.id/id/eprint/125723
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