Saraswasta, I Wayan Gede (2014) Efek Ekstrak Etanol Cacing Tanah (Pheretima aspergillum) Terhadap Penurunan Tanda Inflamasi Eritema Pada Perawatan Ulkus Diabetik Derajat II Tikus Wistar. Sarjana thesis, Universitas Brawijaya.
Abstract
Ulkus diabetik merupakan komplikasi kronik diabetes melitus berupa luka terbuka pada permukaan kulit yang dapat disertai adanya kematian jaringan setempat. Terapi perawatan ulkus diabetik yang adekuat diharapkan dapat mempercepat proses penyembuhan luka secara optimal. Cacing tanah (Pheretima aspergillum) memiliki komponen bioaktif Polifenol sebagai antiinflamasi dan EGF (Epidermal Growth Factor) yang memfasilitasi regenerasi sel epidermal dan memainkan peran penting dalam proses penyembuhan luka dermal melalui percepatan proses inflamasi sehingga dapat menstimulasi poliferasi. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak cacing tanah terhadap penurunan tanda inflamasi eritema pada tikus yang diinduksi ulkus diabetik derajat II. Penelitian ini menggunakan desain true experimental posttest only controlled group. Sampel dibagi ke dalam lima kelompok: Normal Salin sebagai kontrol negatif, Hidrogel sebagai kontrol positif, dan tiga kelompok perlakuan mendapat ekstrak cacing tanah secara topikal, oral, dan topikal-oral. Variabel yang diteliti adalah penurunan tanda inflamasi eritema (dihitung pada hari ke-1 sampai hari ke-7 rawat luka). Hasil penelitian menunjukkan kelompok perlakuan yang mendapatkan ekstrak cacing tanah secara bermakna memiliki nilai rata-rata eritema yang lebih rendah dibandingkan dengan kelompok kontrol (p=0.000). Pemberian ekstrak cacing tanah secara topikal-oral memiliki efek optimal terhadap penurunan nilai rata-rata eritema. Dapat disimpulkan bahwa ekstrak cacing tanah (Pheretima aspergillum) dapat menurunkan tanda infllamasi eritema pada tikus model diabetik.
English Abstract
Diabetic ulcer is one of the chronic complication of diabetes mellitus in the form of an open wound on the skin surface which can be accompanied by local tissue death. Adequate treatment of diabetic ulcer is expected to accelerate the healing process optimally. Earthworm (Pheretima aspergillum) has bioactive components of Polifenol as an antiinflammatory and EGF (Epidermal Growth Factor) which facilitates regeneration of epidermal cells and plays an important role in dermal wound healing process through acceleration of the inflammatory process that can stimulate proliferation. This study aimed to find out the effect of earthworm extract (Pheretima aspergillum) on the decrease signs of inflammation erythema in rats induced diabetic ulcer stage II. This study applied a true-experimental posttest only controlled group design. Samples were divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. The variable studied were the decrease signs of inflammation erythema (calculated on the 1st day till the 7th days of wound care). The results showed that the treatment group gain significant earthworm extract has an average erythema score lower than the control group (p = 0.000). The administered of earthworm extract via topical-oral has an optimal effect on the decreasing signs of inflammation erythema. It can be concluded that the extract of earthworm (Pheretima aspergillum) decrease the signs of inflammation erythema in diabetic rat models.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/645/051407732 |
| Uncontrolled Keywords: | ulkus diabetik, cacing tanah (Pheretima aspergillum), eritema; diabetic ulcer, earthworm (Pheretima aspergillum), erythema |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.4 Diseases of endocrine, hematopoietic, lymphatic, glandular system; diseases of male breast > 616.46 Diseases of islands of Langerhans > 616.462 Diabetes mellitus |
| Divisions: | Fakultas Kedokteran > Ilmu Keperawatan |
| Depositing User: | Hasbi |
| Date Deposited: | 19 Nov 2014 10:37 |
| Last Modified: | 07 Dec 2021 15:46 |
| URI: | http://repository.ub.ac.id/id/eprint/124661 |
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