Siskaningrum, Auliasari (2014) Efektifitas Hidrogel Binahong (Anredera Cordifolia (Ten.) Steenis) Terhadap Luas Luka Pada Tikus Hiperglikemia (Rattus Norvegicus) Galur Wistar. Sarjana thesis, Universitas Brawijaya.
Abstract
Hiperglikemia merupakan awal dari diabetes mellitus. Hiperglikemia dapat menyebabkan luka yang sukar sembuh. Pengobatan luka mulai dikembangkan terutama dari bahan-bahan alami. Binahong mengandung senyawa antioksidan, antimikroba dan flavonoid golongan isoflavon yang menghasilkan aktivitas antinociceptif dan antiinflamasi. Penelitian ini bertujuan mengetahui pengaruh pemberian hidrogel binahong (Anredera Cordifolia (Ten.) Steenis) terhadap luas luka pada tikus hiperglikemia (Rattus norvegicus) galur wistar. Penelitian ini true eksperimental dengan Post-test Only, Control Group Design. Sampel dipilih dengan simple random sampling dibagi menjadi 6 kelompok, masing-masing terdiri dari 3 ekor tikus. Kelompok I (Kontrol negatif) tikus sehat diberi NS 0,9% , kelompok II (Kontrol positif) tikus hiperglikemia diberi NS 0,9, kelompok III diberi hidrogel dan Kelompok IV, V dan VI (perlakuan) diberi hidrogel binahong konsentrasi 2,5%, 5% dan 7,5% selama 12 hari. Variabel yang diukur luas luka pada hari ke-4, 8, 12 dan 16. Analisa data One way ANOVA menunjukkan luas luka berbeda signifikan dengan p = 0.021 < α (0,05) pada hari ke-12. Dilanjutkan uji Tukey HSD ada perbedaan signifikan antara kelompok perlakuan hidrogel binahong konsentrasi 7,5% dengan kelompok Kontrol II tikus hiperglikemia diberi NS 0,9% , p = (0.01) < α (0.05). Kesimpulannya pemberian hidrogel binahong 7,5% (Anredera Cordifolia (Ten.) Steenis) dapat menurunkan luas luka yang menunjukkan perbedaan signifikan pada hari ke-12.
English Abstract
Hyperglycemia is the beginning of diabetes mellitus. Hyperglycemia can cause injury that is difficult to heal. Wound treatment was developed primarily from natural ingredients. Binahong contains antioxidant compounds, antimicrobial, and isoflavone class of flavonoids that produces anti-inflammatory activity and antinociceptif . This study aims to determine the effect of hydrogel binahong (Anredera cordifolia (Ten.) Steenis) toward hyperglycemia extensive wounds in rats (Rattus norvegicus) wistar strain. This research is true experimental with Post-test only, control group design. The sample was selected by simple random sampling were divided into 6 groups, each consists of three rats. Group I (negative control) healthy mice were given NS 0.9%, group II (positive control) hyperglycemic mice were given NS 0.9, Group III and Group IV were given hydrogel, V and VI (treatment) were given hydrogel binahong which had concentration of 2.5%, 5%, and 7.5% for 12 days. Variables measured for the extensive wounds were on days 4, 8, 12, and 16. One-way ANOVA analysis of the data shows the wound area was significantly different with p = 0.021 < α (0.05) on day 12. It was continued by using Tukey HSD test which gave no significant differences between treatment groups binahong hydrogel concentration of 7.5 % with the control group, p = (0.01) < α (0.05). In conclusion, granting binahong hydrogel 7,5% (Anredera cordifolia (Ten.) Steenis) can reduce the size of the wound .
Other obstract
-
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/209/051402568 |
| Uncontrolled Keywords: | Hidrogel Binahong, Luas Luka, Hiperglikemia; HydrogelBinahong, WideWounds, Hyperglycemia |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.4 Diseases of endocrine, hematopoietic, lymphatic, glandular system; diseases of male breast > 616.46 Diseases of islands of Langerhans > 616.462 Diabetes mellitus |
| Divisions: | Fakultas Kedokteran > Ilmu Keperawatan |
| Depositing User: | Hasbi |
| Date Deposited: | 07 May 2014 08:17 |
| Last Modified: | 02 Dec 2021 06:37 |
| URI: | http://repository.ub.ac.id/id/eprint/124182 |
Preview |
Text
SKRIPSI_AULIASARI SISKANINGRUM.pdf Download (6MB) | Preview |
Actions (login required)
 |
View Item |