Korelasi Pemeriksaan Human Epidermal Growth Factor-2 (HER-2) dengan Stadium klinis TNM Pada Pasien Kanker Payudara di Instalasi Patologi Anatomi RS Syaiful Anwar Periode Januari 2010 – Desember 2012

Mukti, AchFahrurRozi (2014) Korelasi Pemeriksaan Human Epidermal Growth Factor-2 (HER-2) dengan Stadium klinis TNM Pada Pasien Kanker Payudara di Instalasi Patologi Anatomi RS Syaiful Anwar Periode Januari 2010 – Desember 2012. Sarjana thesis, Universitas Brawijaya.

Abstract

Kanker payudara merupakan kanker yang sering muncul pada wanita dan menempati urutan kedua setelah kanker paru-paru sebagai kanker yang mematikan. Salah satu permasalahan utama kanker payudara ialah kesulitan dalam menentukan prognosis terkait keterlibatan proses metastasis sebagai salah satu kriteria stadium klinis TNM.Telah banyak penelitian mengenai faktor prognostik terhadap kanker payudara agar modalitas terapi kanker payudara semakin baik. Salah satunya tes HER-2 melalui pemeriksaan imunohistokimia. Namun pemeriksaan ini masih relatif mahal dan sulit ditemui di Indonesia. Penelitian ini bertujuan untuk mengetahui apakah ada korelasi antara ekspresi HER-2 dengan stadium klinis TNM pada pasien kanker payudara. Penelitian ini merupakan penelitian cross sectional yang dilakukan di Instalasi Patologi Anatomi RS dr. Saiful Anwar Malang. Sampel penelitian yaitu pasien kanker payudara yang melakukan pemeriksaan di Instalasi Patologi Anatomi RS dr. Saiful Anwar Malang periode Januari 2010 hingga Desember 2012 yang memenuhi kriteria inklusi dan eksklusi, yaitu jaringan kanker payudara yang telah diperiksa immunohistokimia untuk dinilai status HER-2 dan dilakukan penentuan stadium klinisnya. Analisis korelasi antara ekspresi HER-2 dengan stadium klinis TNM diuji dengan uji Spearman’s rho. Hasil penelitian menunjukkan tidak ada hubungan yang signifikan antara status HER-2 dengan stadium klinis TNM (p = 0,871; r = -0,018; N = 89). Kesimpulan dari penelitian ini adalah tidak ada korelasi yang signifikan antara ekspresi HER-2 dengan stadium klinis TNM pada penderita kanker payudara di instalasi patologi anatomi RS dr. Saiful Anwar Malang periode Januari 2010 sampai Desember 2012

English Abstract

Breast cancer is cancer that frequently appears in women and ranks second after the lung cancer as cancer that leads to death. One of the main problem of breast cancer is the difficulty in determining the prognosis of metastatic involvement process as one of the criteria for clinical stage TNM. There are many research on prognostic factors for breast cancer, so that breast cancer treatment modalities are getting better. One of them is HER-2 test using immunohistochemistry examination. But this examination is still relatively expensive and difficult to find in Indonesia. This study aims to determine whether there is a correlation between HER-2 expression with clinical stage TNM in patients with breast cancer. This study was a cross sectional study conducted in pathology anatomy department of hospital dr. Saiful Anwar Malang. The research sample are breast cancer patients who checks at the pathology anatomy department of hospital dr. Syaiful Anwar Malang period January 2010 to December 2012 who meet the inclusion and exclusion criteria, which breast cancer tissue had been examined using immunohistochemistry to assess the status of HER-2 and conducted it’s clinical staging. Correlation Analysis between HER-2 expression with clinical staging was tested with Spearmans rho test. The results showed no significant association between HER-2 status with clinical staging (p = 0,871; r = -0,018; N = 89). The conclusion of this study there is no significant correlation between HER-2 expression with clinical stage TNM in patients with breast cancer in pathology anatomy department of hospital dr. Syaiful Anwar Malang period January 2010 to December 2012.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2014/117/051401744
Subjects: 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel
Divisions: Fakultas Kedokteran > Pendidikan Dokter
Depositing User: Hasbi
Date Deposited: 11 Mar 2014 10:53
Last Modified: 21 Oct 2021 07:13
URI: http://repository.ub.ac.id/id/eprint/124082
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