Chuan, LeongZhee (2013) Efek Antifungal Ekstrak Etanol Daun Sirsak (Annona Muricata) Pada Pertumbuhan Candida Albicans In Vitro. Sarjana thesis, Universitas Brawijaya.
Abstract
Candidiasis Is A Condition Commonly Caused By C andida Albicans And Is Present As Normal Flora In The Skin And Mucous Membranes. It Can Grow Out Of Control And Cause Candidiasis When There Are Body Environment Changes. The Prevention Of Futher Complication And Treatment Focus Is On How To Combat The Organism In Susceptible Persons Effectively. Annona Muricata Possesses Active Substances Such As Annonaceous Acetogenins, Gentisic Acid And Condensed Tannins Which Could Induce The Death Of Candida Albicans Cells And Is Belived To Be An Alternative Treatment For Candidiasis. The Objective Of This Research Was To Determine The Effect Of Annona Muricata Leaf Ethanol Extract On The Growth Of Candida Albicans In Vitro. The Research Design Used Was Experimental Laboratory Study Using The Tube Dilution Test On Sabouraud’s Dextrose Broth Medium To Determine The Minimum Inhibitory Concentration (MIC) And The Streaking Stage On A Sabouraud’s Dextrose Agar Plate To Determine The Minimum Fungicidal Concentration (MFC). The Annona Muricata Leaf Extract Concentration Used Were 32.5%, 35%, 37.5%, 40%, 42.5% And 45%. The Results Were Analyzed Using The One-Way ANOVA. The Fungicidal Concentration Of Annona Muricata Extract Is 45% And The Correlation Coefficient, R = -0.956 Shows That There Is Decrease In The Colony Number As The Concentration Increases. In Conclusion, Annona Muricata Leaf Ethanol Extract Inhibits Candida Albicans And Could Be Used As An Alternative Anti-Fungal Treatment For Candidiasis
English Abstract
Kandidiasis Merupakan Kondisi Infeksi Jamur Yang Bisanya Disebabkan Oleh Candida Albicans Yang Ditemui Sebagai Flora Normal Di Permukaan Kulit Dan Membran Mukosa Kita. Ia Bias Berkembang Biak Diluar Kendali Dan Menyebabkan Kandidiasis Apabila Lingkungan Dalam Tubuh Kita Berubah. Pencegahan Dari Komplikasi Dan Pengobatannya Berfokus Pada Penanganan Secara Efektif Terhadap Organisme Ini, Yang Terdapat Pada Orang Yang Beresiko. Daun Annona Muricata Memiliki Bahan Aktif Berupa Annonaceous Acetogenins, Gentisic Acid Dan Condensed Tannins Yang Bisa Mematikan Sel Candida Albicans Dan Dipercayai Sebagai Pengobatan Alternatif Untuk Candidiasis. Tujuan Penelitian Ini Adalah Untuk Menentukan Efek Ekstrak Etanol Daun Annona Muricata Pada Pertumbuhan Candida Albicans In Vitro. Desain Penelitian Yang Digunakan Adalah Penelitian Laboratori Eksperimental Yang Menggunakan Tes Dilusi Tabung Untuk Menentukan Kadar Hambat Minimalnya (KHM) Menggunakan Sabouraud’s Dextrose Broth Dan Stadium Streaking Pada Plat Sabouraud’s Dextrose Agar Untuk Menentukan Kadar Bunuh Minimalnya (KBM). Konsentrasi Ekstrak Daun Annona Muricata Yang Digunakan Adalah 32.5%, 35%, 37.5%, 40%, 42.5% Dan 45%. Data Hasilnya Dianalisa Dengan Menggunakan Metode One-Way ANOVA. Konsentrasi Fungicidal Di Eksperimen Ini Ialah 45% Dan Correlation Coefficient, R = -0.956 Menunjukan Bahwa Ada Pengurangan Jumlah Coloni Apabila Konsentrasi Ekstrak Meningkat. Kesimpulannnya Adalah Ekstrak Etanol Daun Annona Muricata Bisa Menghambat Pertumbuhan Candida Albicans Dan Berpotensi Sebagai Pengobatan Alternatif Untuk Kandidiasis
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2013/667/051400339 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 24 Jan 2014 14:59 |
| Last Modified: | 21 Oct 2021 03:33 |
| URI: | http://repository.ub.ac.id/id/eprint/123956 |
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