Dejaneira, Febrilla (2013) Efek Radiasi Sinar Gamma Terhadap Apoptosis Sel Epitel Kolon Rattus Norvegicus Varian Wistar Jantan Dengan Parameter Gambaran Caspase-3. Sarjana thesis, Universitas Brawijaya.
Abstract
Radioterapi Merupakan Salah Satu Modalitas Terapi Keganasan. Namun, Radiasi Yang Ditujukan Pada Sel Ganas Juga Mempengaruhi Sel Sehat Di Sekitarnya. Kolon Merupakan Organ Yang Dapat Terkena Pengaruh Buruk Radiasi Karena Memiliki Radiosensitivitas Yang Tinggi. Sinar Gamma Berinteraksi Dengan Molekul Tubuh Menyebabkan Kerusakan Dna Dan Aktivasi Ceramide , Memicu Terbentuknya Ros Kemudian Apoptosis. Caspase-3 Berperan Penting Pada Apoptosis Sebagai Caspase Efektor. Tujuan Penelitian Adalah Untuk Membuktikan Bahwa Pemberian Radiasi Sinar Gamma Co 60 Pada Rattus Norvegicus Varian Wistar Jantan Menyebabkan Apoptosis Sel Epitel Kolon Dengan Jumlah Sel Apoptosis Yang Lebih Banyak Pada Dosis Tunggal Daripada Fraksinasi. Penelitian Merupakan Penelitian Eksperimental Dengan Rancangan Perlakuan Tunggal. Hewan Coba Dibagi Secara Acak Menjadi 3 Kelompok, Yaitu : Kontrol (Tidak Diberi Radiasi Sinar Gamma, N=9), Tunggal (Diberi Radiasi Dosis Tunggal 10 Gy, N=9) Dan Fraksinasi (Diberi Radiasi Dosis Fraksinasi 5x2 Gy, N=9). Hasil Penelitian Menunjukkan Peningkatan Indeks Apoptosis Pada Sel Epitel Kolon Yang Diradiasi Secara Signifikan (Anova, P>0,05). Secara Berurutan, Indeks Apoptosis Tertinggi Pada Kelompok Fraksinasi, Tunggal, Dan Kontrol. Kesimpulan Penelitian Adalah Pemberian Radiasi Sinar Gamma Co 60 Menyebabkan Apoptosis Sel Epitel Kolon Rattus Norvegicus Varian Wistar Jantan Dan Dosis Tunggal Tidak Menyebabkan Apoptosis Sel Epitel Kolon Lebih Banyak Daripada Dosis Fraksinasi
English Abstract
Radiotherapy Is One Of The Cancer Therapy Modalit ies . However, Irradiation To Cancer Cells Can Also Give Side Effect To Normal Cells. Colon Is Radiosensitive Organ That Can Be Affected By Irradiation . Gamma Rays Interact With Body’s Molecules Lead To Dna Damage And Ceramide Activation, Thus, Ros Formation And Later, Apoptosis. Caspase-3 Plays Important Role On Apoptosis As Effector Caspase. The Objective Of This Research Was To Determin e Whether 10 Gy Single Dose Of Co 60 Gamma Rays To Male Wistar Variant Rattus Norvegicus Increas ing The Apoptotic Of Epithelial Cells In Colon Higher Than 5x2 Gy Fractionated Dose Of Co 60 Gamma Rays. This Research Was Designed As Post-Test Only Experimental Study. The Animals Were Randomly Classified Into 3 Groups: Control (No Gamma Rays Irradiation , N=9), Single-Dose (10 Gy Single-Dose Gamma Irradiation, N=9), And Fractionated-Dose (5x2 Gy Fractionated-Dose Gamma Irradiation, N=9). Result Show ed Signficantly Increasing Apoptotic Index Of Irradiated Colonic Epithelial Cells (Anova, P>0,05). The Highest Apoptotic Index Wa s On Fractionated-Dose, Single-Dos e , And Control Group Respectively. The Conclusion Wa s Gamma Rays Irradiation Caus ing Colon Epithelial Cells Apoptotic A nd Single - Dose Irradiation C ould Not Increase The Apoptotic Index Of Epithelial Cells In Colon Higher Than Fractionated
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2013/662/051400227 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 22 Jan 2014 08:08 |
| Last Modified: | 21 Oct 2021 03:22 |
| URI: | http://repository.ub.ac.id/id/eprint/123952 |
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