Dewi, Sitya (2013) Pengaruh Pemberian Tepung Jamur Tiram Putih (Pleurotus ostreatus) Terhadap Kadar LDL Tikus Putih Strain Wistar (Rattus norvegicusstrain Wistar)Yang Diberi Diet Aterogenik. Sarjana thesis, Universitas Brawijaya.
Abstract
Dislipidemia merupakan gangguan metabolisme lipoprotein yang salah satunya ditandai oleh peningkatankadar LDL di dalam darah. JamurTiramPutih merupakan suatu bahanmakananyang banyakmengandung zatgizidansenyawalain yang dibutuhkanolehtubuhdiantaranyasenyawa lovastatin.Senyawa lovastatin merupakansenyawa inhibitor kompetitif HMG-KoA reduktase yang mampu menurunkan kolesterol plasma dengan efek samping kecil.Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian tepung jamur tiram putih (Pleurotus ostreatus) terhadap kadar LDL tikus putih (Rattus norvegicus strain Wistar)yang diberi diet aterogenik. Penelitian ini menggunakanstudieksperimentaldengan desain penelitian Posttest Control Group yang dilakukan pada 30 ekor tikus jantan yang dibagi secara random menjadi 5 kelompok. Kelompok I adalah tikus yang diberi pakan normal (kontrol negatif), kelompok II diberi diet aterogenik (kontrol positif), kelompok III diberi diet aterogenik dan tepungjamurtiramputih 25 mg, kelompok IV diberi diet aterogenik dantepungjamurtiramputih 50 mg dan kelompok V diberi diet aterogenik dan tepungjamurtiramputih 100 mgselama 8 minggu.Hasilpenelitianmenunjukkanbahwakadar LDL antarakelimakelompokberbedasecarabermakna (Kruskall Wallis, p=0.02) .Kesimpulan penelitian ini adalahpemberian tepungjamurtiramputihdapatmenurunkan kadar LDL tikus putih(Rattus norvegicus strain Wistar) yang diberi diet aterogenik. Dosis optimaladalah pada kelompok perlakuan IV yaitu dengan dosis 50 mg.
English Abstract
Dyslipidemia is lipoprotein metabolism disorder which is marked by an increasing of LDL in blood serum. White Oyster Mushroom contains a lot of nutrients and other substances needed by the body such as the compound lovastatin.Lovastatin is a compound competitive inhibitor of HMG-CoA reductase were able to lower plasma cholesterol with little side effects.The aims of this study to find out effect of white oyster mushrooms flour (Pleurotus ostreatus) that can decreaseLDL level of rats (Rattus norvegicus strain Wistar) with atherogenic diet. This study used the control group posttest design in 30 male rats that is divided randomly into 5 groups. First group was given normal diet (negative control), second group was given atherogenic diet (positif control), third group was given atherogenic diet and 25 mgwhite oyster mushrooms flour, fourth group was given atherogenic diet and 50 mgwhite oyster mushrooms flour and the fifth group was given atherogenic diet and 100 mgwhite oyster mushrooms flour for 8 weeks. Result showed LDL level among fifth group is different (Kruskall Wallis, p=0,02). The conclusion of this study is white oyster mushrooms flour can decreaseLDL level of rats (Rattus norvegicus strain Wistar) with atherogenic diet. The optimum dossage of white oyster mushrooms flour is in fourth groups of treatment that was given 50 mg
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2013/445/051306184 |
| Subjects: | 600 Technology (Applied sciences) > 613 Personal health and safety > 613.2 Dietetics |
| Divisions: | Fakultas Kedokteran > Ilmu Gizi |
| Depositing User: | Hasbi |
| Date Deposited: | 26 Jul 2013 09:54 |
| Last Modified: | 19 Oct 2021 01:59 |
| URI: | http://repository.ub.ac.id/id/eprint/123728 |
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