Nurhuda, YusaAmin (2013) Hubungan antara Status Reseptor Progesteron dengan Metastasis Kelenjar Getah Bening pada Carcinoma Mammae. Sarjana thesis, Universitas Brawijaya.
Abstract
Latar belakang: Metastasis kelenjar getah bening, ukuran tumor, grade tumor, status reseptor estrogen, dan status reseptor progesteron merupakan faktor prognostik penting dari carcinoma mammae . Hubungan antara tingkat histologis carcinoma mammae dengan status reseptor progesteron telah ditemukan. Penelitian mengenai hubungan antara status reseptor progesteron dengan metastasis kelenjar getah bening masih sangat sedikit. Tujuan: Untuk mengetahui apakah terdapat hubungan antara status reseptor progesteron dengan metastasis kelenjar getah bening pada carcinoma mammae . Metode: Penelitian observasional kasus-kontrol dengan mencatat data rekam medis penderita carcinoma mammae di Instalasi Patologi Anatomi Rumah Sakit Saiful Anwar periode Januari 2010-Desember 2011. Data yang diambil adalah data ada/tidaknya metastasis kelenjar getah bening dan data ada/tidaknya reseptor progesteron pada pemeriksaan imunohistokimia kelenjar mammae oleh Dokter Ahli Patologi Anatomi. Hasil: Diantara 111 penderita tumor mammae, hanya 56 kasus yang memenuhi kriteria inklusi. Pada uji odds ratio menunjukkan odds ratio bernilai 1 artinya penderita yang memiliki reseptor progesteron positif dan penderita yang memiliki reseptor progesteron negatif memiliki nilai risiko yang sama untuk terjadinya metastasis kelenjar getah bening. Uji signifikansi odds ratio menunjukkan p = 1 (p > 0,05) artinya hubungan antara reseptor progesteron dengan metastasis kelenjar getah bening pada carcinoma mammae dinyatakan tidak bermakna. Kesimpulan: Tidak ada hubungan antara status reseptor progesteron dengan metastasis kelenjar getah bening pada carcinoma mammae .
English Abstract
Background: Lymph node metastasis, tumor size, tumor grade, estrogen receptor status and progesterone receptor status are important prognostic factors of carcinoma mammae . The association between histological grade of carcinoma mammae and progesterone receptor status had already been found. The study of the association between progesterone receptor status and lymph node metastasis is unclear. Objective: To investigate the association between progesterone receptor status and lymph node metastasis in carcinoma mammae . Method: Observational case-control study by collecting medical records of carcinoma mammae patients from Departement of Anatomic Pathology in Saiful Anwar Hospital from January 2010 to December 2011. We collected data about the existence of lymphnode metastasis and data about the existence of progesterone receptor from immunohistochemistry pro cedure performed by pathologist. Results: Among 111 patients with carcinoma mammae , only 56 cases met the inclusion criteria. Odds ratio test showed that the value of odds ratio was 1; it means that patients who have positive progesterone receptor and patients with negative progesterone receptor had the same value for the risk of lymph node metastasis. Odds ratio significance test showed p = 1 (p > 0.05); it means that there was no association between progesterone receptor and lymph node metastasis in carcinoma mammae . Conclussion: There is no association between progesterone receptor status and lymph node metastasis in carcinoma mammae .
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2013/36/051301947 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Endang Susworini |
| Date Deposited: | 13 Mar 2013 15:42 |
| Last Modified: | 13 Mar 2013 15:42 |
| URI: | http://repository.ub.ac.id/id/eprint/123639 |
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