Herdiansyah, Syahrullah (2021) Hubungan Faktor Resiko Infeksi Carbapenem Resistant Acinetobacter baumannii (CRAB) Pada Pasien Dewasa di Asia: Systematic Review. Sarjana thesis, Universitas Brawijaya.
Abstract
Antibiotik golongan karbapenem merupakan antibiotik pilihan untuk terapi infeksi yang disebabkan oleh Acinetobacter baumannii yang resistan terhadap antibiotik lini pertama tersebut. Namun demikian, penggunaan antibiotik karbapenem berpotensi menimbulkan terjadinya strain Acinetobacter baumannii yang resistan terhadap karbapenem (Carbapanem Resistant Acinetobacter baumanii). Analisis faktor risiko infeksi Carbapenem resistant Acinetobacter baumannii (CRAB) penting diketahui oleh tenaga kesehatan dalam mempertimbangkan pemberian suatu terapi medika mentosa maupun terapi invasif agar meminimalisir terjadinya infeksi. Pada studi literatur, tidak dapat dilakukan perbandingan pada faktor resiko usia, durasi rawat inap, dan penyakit chronic kidney disease. Selain itu, pada faktor resiko yang lain, hasil analisis penelitian menunjukkan nilai OR=1,07, 95% CI=0,65-1,78; I2=0%; P=0,78 pada faktor resiko cerebrovascular disease, nilai OR=1,33, 95% CI=0,84-2,11; I2=20%; P=0,23 pada faktor resiko diabetes mellitus, nilai OR=19,3, 95% CI=2,23-167,34; I2=86%; P=0,007 pada faktor resiko penggunaan antibiotik karbapenem, dan nilai OR=1,85, 95% CI=0,56-6,16; I2=81%; P=0,32 pada faktor resiko penggunaan ventilator mekanik. Sehingga didapatkan bahwasanya yang menjadi faktor resiko yang signifikan dari infeksi CRAB adalah riwayat penggunaan karbapenem. Sedangkan, riwayat usia pasien, durasi rawat inap, penggunaan ventilator, dan riwayat penyakit bawaan seperti chronic kidney disease, diabetes mellitus, dan penyakit cerebrovascular tidak menjadi faktor resiko infeksi CRAB yang signifikan.
English Abstract
Carbanem group antibiotic is drug of choice to treat infection that caused by Acinetobacter baumannii that resistant with first line antibiotic. However, the usage of carbapenem antibiotic has a potential to induce Acinetobacter baumannii strain that resistent with carbapenem / Carbapenem Resistant Acinetobacter baumannii (CRAB). Analysis of CRAB risk factor is necessary to be known by health worker to give a consideration to give an appropriate therapy for this disease and minimalize its mortality and morbidity. In literature review, comparation of age, hospitalization duration, and chronid kidney disease cant be compared because of lack of data. In analytical approach of another risk factor, we get OR=1,07, 95% CI=0,65-1,78; I2=0%; P=0,78 on comparation of patient with cerebrovascular disease, OR=1,33, 95% CI=0,84-2,11; I2=20%; P=0,23 on comparation of patient with diabetes mellitus, OR=19,3, 95% CI=2,23-167,34; I2=86%; P=0,007 on comparation of patient that get carbapenem antibiotic therapy, and OR=1,85, 95% CI=0,56-6,16; I2=81%; P=0,32 on comparation of patient with the usage of mechanical ventilator. Because of that, it can be said that the significant risk factor for CRAB is the usage of carbapenem. However, another risk factor such as age of patient, hospitalization duration, ventilator usage, and patient with history of chronid kidney disease, diabetes mellitus, and cerebrovascular disease is not a significant risk factor for CRAB infection.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 610 |
| Uncontrolled Keywords: | Carbapenem Resistant Acinetobacter baumanii, karbapenem, faktor resiko, usia, durasi rawat inap, penggunaan ventilator, diabetes mellitus, chronic kidney disease, penyakit cerebrovascular, Carbapenem Resistant Acinetobacter baumanii, carbapenem, risk factor, age, hospitalization duration, ventilator usage, diabetes mellitus, chronic kidney disease, cerebrovascular disease. |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Unnamed user with email gaby |
| Date Deposited: | 24 Oct 2021 05:39 |
| Last Modified: | 24 Feb 2022 06:43 |
| URI: | http://repository.ub.ac.id/id/eprint/185757 |
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