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Mahendra, Gede Ari (2020) Uji Efektivitas Ekstrak Etanol Daun Kamboja Putih (Plumeria acuminta) Terhadap Bakteri Shigella dysenteriae Secara In vitro. Sarjana thesis, Universitas Brawijaya.

Indonesian Abstract

Shigella dysenteriae merupakan bakteri penyebab penyakit disentri basiler. Bakteri ini menyebabkan radang usus dan mengakibatkan gejala-gejala seperti diare, tenesmus, serta darah dan lendir dalam tinja. Di Indonesia, terdapat laporan Shigella dysenteriae resisten terhadap kotrimoksazol. Pengobatan alternatif perlu dikembangkan untuk mengatasi infeksi Shigella dysentriae yang resisten. contohnya dengan menggunakan bahan alam, yaitu daun kamboja putih. Potensi yang dimiliki daun kamboja putih sebagai antibakteri karena mengandung bahan aktif flavonoid, dan tanin. Metode yang digunakan adalah difusi sumuran dengan konsentrasi ekstrak 50%, 60%, 70%, 80%, 90% dan dilakukan pengulangan sebanyak empat kali, didapatkan rata-rata hasil berturut-turut 9,27 mm, 9,61 mm, 11,34 mm, 11,63 mm, 12,44 mm. Hasil uji One-Way ANOVA menunjukan nilai p<0,05 yang menunjukkan adanya pengaruh signifikan dari ekstrak daun kamboja terhadap diameter zona inhibisi . Terdapat korelasi positif antara dua variabel, ditunjukan pada uji korelasi Spearman. Disimpulkan bahwa ekstrak daun kamboja putih memiliki efek antimikroba terhadap bakteri Shigella dysenteriae secara in vitro.

English Abstract

Shigella dysenteriae is a bacterium that causes bacillary dysentery. It causes inflammation of the intestine and shows symptoms such as diarrhea, tenesmus, and blood and mucus in the stool. In Indonesia, there were reports of Shigella dysenteriae resistant to cotrimoxazole. Therefore, an alternative medicine needs to be found to treat resistant Shigella dysentriae infections. For example using natural herbs such as the white frangipani leaves. The white frangipani leaves may have antibacterial effect because it contains active substances such as flavonoids, and tannins. This research used the well diffusion method with extract concentrations of 50%, 60%, 70%, 80%, 90% and repeated four times. The average of inhibition zone were 9.27 mm, 9.61 mm, 11.34 mm, 11.63 mm, and 12.44 mm, respectively. The One-Way ANOVA test results showed a p value <0.05, which showed a significant effect between frangipani leaf extract and the diameter of the inhibition zone. The Spearman correlation test showed a positive correlation between the two variables. As conclusion, white frangipani leaf extract has antimicrobial effect on Shigella dysenteriae bacteria in vitro.

Other Language Abstract

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Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2020/5/052003445
Uncontrolled Keywords: Shigella dysenteriae, kamboja putih, potensi antimikroba, Shigella dysenteriae, white frangipani, antimicrobial potential
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms
Divisions: Fakultas Kedokteran > Pendidikan Dokter
Depositing User: Budi Wahyono
URI: http://repository.ub.ac.id/id/eprint/181355
Text
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