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Jasmine S., Azzura (2019) Uji Toksisitas Subkronis Oral Ekstrak Etanol Ubi Jalar Ungu(Ipomoea batatas L)Kultivar Gunung Kawi terhadap Perubahan Kadar Kolesterol Total dan Trigliserida Rattus Norvegicus Strain Wistar. Sarjana thesis, Universitas Brawijaya.

Indonesian Abstract

Perkembangan fitoterapi yaitu pengobatan herbal menjadi penting dalam upaya pengobatan dan prevensi penyakit. Ubi jalar ungu(Ipomoea batatas L.) kultivar gunung kawi menjadi pilihan bahan tanaman karena mengandung nutrisi tinggi dan dikenal memiliki kandungan dominan yaitu antosianin. Antosianin memiliki banyak manfaat bagi tubuh salah satunya mampu menurunkan profil lipid seperti kolesterol total dan trigliserida dgn mekanisme down regulation HMG-CoA reductase. Penelitian ini bertujuan untuk mengetahui pengaruh paparan subkronis ekstrak etanol ubi jalr ungu terhadap perubahan kadar kolesterol total dan trigliserida pada sampel tikus putih strain Wistar Rattus norvegicus sebagai langkah pengembangan keamanan obat herbal. Paparan ekstrak etanol diberikan selama 90 hari(subkronis) dgn diet normal pada 3 kelompok dosis terpapar;10,20 dan 40 mg/kgBB dan kontrol kepada 10 tikus jantan dan 10 tikus betina pada masing-masing kelompok dgn total tikus 80 ekor. Hasil paparan baik kolesterol total dan trigliserida berada dalam rentang normal. Rentang normal kolesterol tikus 40-130 mg/dL & 26-145 mg/dL untuk TG. Tidak didapat dampak perubahan bermakna pada nilai kolesterol total betina & jantan dan didapat pengaruh bermakna antar dosis pada kelompok trigliserida jantan antar dosis 10-20 mg/kgBB dan 10-40 mg/kgBB. Secara umum, pengaruh ekstrak etanol dosis 10,20 dan 40 mg/kgBB masih tergolong aman karena berada pada rentang normal. Alhasil, paparan subkronis oral ekstrak etanol dari Ipomoea batatas L. tergolong aman.

English Abstract

The development of phytotheraphy or herbal medicine nowadays is getting more important as a way of curing & preventing a disease. Sweet potato (Ipomoea batatas L.) Kawi Mountain Cultivar has become a plant of choice due to its nutritional value and known to contain Anthocyanin as one of the major substances. Anthocyanin known to have variety of advantageable effects such as lowering lipid profile; total cholesterol and triglycerides with a down regulation mechanism of HMG CoA reductase. The main purpose of this experiment is to evaluate the sub-chronic effect of ethanol extract of Ipomoea batatas L. towards changes in TC and TG level in white Wistar rats (Rattus norvegicus) as a step on developing safety profile of the upcoming herbal drug. Ethanol extract were exposed for 90 days (sub chronic) in total with a normal diet in 3-exposed dosage groups (10,20 and 40 mg/kgBW) and control group with 10 female and 10 male rats in each dosage group. The results show that both TC and TG of all control and exposed groups are in normal range. The normal range reference for rats are 40-130 mg/dl in cholesterol level and 26-145 mg/dl for triglycerides. There is no significant change in cholesterol levels of female& male rat. There are significant changes in male rat’s triglycerides within dose 10-20 mg/kgBW & 10-40 mg/kgBW. In general, all dosed-exposed group (10,20 and 40 mg/kgBW) are considered safe since values are within normal range. Thus, sub-chronic exposure of ethanol extract of Ipomoea batatas L. is safe.

Other Language Abstract

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Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2019/416/052001261
Uncontrolled Keywords: Ipomoea batatas L., Kolesterol Total(TC), Trigliserida(TG), Ipomoea batatas L., Total Cholesterol(TC), Triglycerides(TG)
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms
Divisions: Fakultas Kedokteran > Pendidikan Dokter
Depositing User: Budi Wahyono
URI: http://repository.ub.ac.id/id/eprint/180108
Text
Azzura Jasmine S (2).pdf

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