Purnamawati, CaturElvi (2014) Hubungan Kadar IL-6 Serum terhadap Kegagalan Terapi Pasien Pneumonia Komunitas Sedang-Berat Disertai Komorbid Penyakit Paru Obstruktif Kronis (PPOK) dan Gagal Jantung. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang : Kegagalan terapi pada pneumonia komunitas berhubungan kurangnya respon terhadap pengobatan antibiotik dan juga tergantung bakteri penyebab, keparahan penyakit, kondisi host dan kadar Interleukin-6 (IL)-6 terhadap kegagalan terapi. Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan kegagalan terapi pada pasien pneumonia komunitas disertai komorbid PPOK dan gagal jantung. Metode : 16 pasien pneumonia komunitas disertai komorbid PPOK dan gagal jantung di rawat inap RSU dr. Saiful Anwar Malang dilihat faktor host berupa umur dan riwayat merokok, bakteri penyebab dan diukur kadar IL-6 serum pada hari ke1, ke-3 dan ke-7 dengan metode ELISA. Hasil : 4 pasien (25 %) mengalami kegagalan terapi, dan keseluruhannya gagal terapi lambat. Dari uji repeated ANOVA didapatkan rerata kadar IL-6 serum pada hari ke -1= 85.83 ± 50.89 pg/ml, hari ke-3= 42.63 ± 23.11pg/ml dan hari ke-7 = 16.94±11.49 pg/ml. Sedangkan dari hasil uji koefisien kontingensi didapatkan umur tidak berhubungan secara signifikan dengan kegagalan terapi (p=0.146), riwayat merokok (p= 0.368), dan bakteri penyebab (p=0.126).Untuk kadar IL-6 dari hasil uji beda independent sample t test pada hari ke-7 berbeda secara signifikan (p= 0.003). Sedangkan dari uji regresi logistik kadar IL-6 serumntidak berpengaruh secara signifikan(p 0.05). Kesimpulan : Kadar IL-6 serum mengalami penurunan dengan terapi pneumonia komunitas dan komorbidnya. Secara statistik, kegagalan terapi tidak berhubungan dengan umur, riwayat merokok, bakteri penyebab dan kadar IL-6 serum.
English Abstract
Background : Treatment failure in community acquired pneumonia is related to lack of response to antibiotic treatment and it also depends on causal microorganism, initial severity of infection, conditions of host and systemic cytokine profile (IL-6). aim of our study was to evaluated factors associated with treatment failure in community acquired pneumonia with comorbidities COPD and heart failure. Methode : 16 patients of CAP with comorbidities COPD and heart failure which is hospitalised in Saiful Anwar Hospital were observed by host factors (age and smoking status), causal microorganism and measurement of serum IL-6 level that were obtained on day 1,3 and 7 with ELISA methode. Result : 4 (25%) out of 16 patients had a failure treatment which is called late failure treatment. Based on Repeated ANOVA analysis, average serum IL-6 level on day 1 = 85.83 ± 50.89 pg/ml, day 3 = 42.63 ± 23.11pg/ml, day 7= 16.94±11.49 pg/ml. According to Contingensi Coefisien analysis, age was not significantly contribute to treatment failure (p=0.146),smoking status (p=0.368), causal microorganism (p=0.126). Sample t test independent analysis showed that serum IL-6 level day 7 was significantly different (p=0.003). Logistic regression analysis revealed that serum IL-6 level was not significantly influenced (p0.05). Conclusion : Serum IL-6 level was decreased with CAP treatment and comorbids. Statistically, treatment failure was not related to age, smoking status, causal microorganism and IL-6 level serum.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.241/PUR/h/041404001 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system |
| Divisions: | Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 28 Aug 2014 10:35 |
| Last Modified: | 28 Aug 2014 10:35 |
| URI: | http://repository.ub.ac.id/id/eprint/158326 |
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