Raharjo, Budiono (2013) Hubungan Antara Kadar Granulocyte Macrophage Colony Stimulating Factor Dan Jumlah Eosinofil Dengan Derajat Rinitis Alergi. Magister thesis, Universitas Brawijaya.
Abstract
Rinitis alergi memberi dampak luas pada kualitas hidup penderita, sehingga diperlukan diagnosis dan penatalaksanaan yang tepat. Granulocyte macrophage – colony stimulating factor bersama IL5 dan IL3 memegang peranan terhadap hematopoesis, pematangan, proliferasi, dan survival eosinofil. Eosinofil diketahui berpengaruh terhadap gejala dan derajat rinitis alergi. Tujuan. Mengetahui hubungan kadar GM-CSF dan jumlah eosinofil dengan derajat rinitis alergi. Metode Penelitian. Observasional analitik dengan pendekatan cross sectional melibatkan 24 penderita rinitis alergi yang bersedia dilakukan pengambilan darah dan sekret mukosa hidung untuk pemeriksaan kadar GM-CSF dan jumlah eosinofil. Hasil. Hubungan kadar GM-CSF serum, GM-CSF mukosa hidung, jumlah eosinofil darah, dan eosinofil mukosa hidung dengan derajat rinitis alergi dianalisa dengan uji korelasi didapatkan p0,05 sehingga tidak ada hubungan yang bermakna. Hubungan kadar GM-CSF serum dengan GM-CSF mukosa hidung dan hubungan jumlah eosinofil darah dengan jumlah eosinofil mukosa hidung dianalisa dengan uji korelasi didapatkan p0,05 sehingga keduanya tidak ada hubungan yang bermakna. Hubungan kadar GM-CSF serum dengan jumlah eosinofil darah dan hubungan kadar GM-CSF mukosa hidung dengan jumlah eosinofil mukosa hidung dianalisa dengan uji korelasi juga didapatkan p0,05 sehingga tidak ada hubungan yang bermakna. Kesimpulan. Tidak terdapat hubungan yang bermakna antara kadar GM-CSF serum, kadar GM-CSF mukosa hidung, jumlah eosinofil darah, dan jumlah eosinofil mukosa hidung dengan derajat rinitis alergi. Tidak terdapat hubungan yang bermakna antara kadar GM-CSF serum dengan kadar GM-CSF mukosa hidung dan antara jumlah eosinofil darah dengan jumlah eosinofil mukosa hidung.Tidak terdapat hubungan yang bermakna antara kadar GM-CSF serum dengan jumlah eosinofil darah dan antara kadar GM-CSF mukosa hidung dengan jumlah eosinofil mukosa hidung.
English Abstract
Allergic rhinitis impact on patient`s quality of life widely, so that necessary for appropriate diagnosis and treatment. Granulocyte macrophage - colony stimulating factor and IL3 with IL5 plays against hematopoesis, maturation, proliferation, and survival of eosinophils. Eosinophils are known to affect degree of allergic rhinitis symptoms. Purpose. Determine relationship of GM-CSF level and eosinophil count with degree of allergic rhinitis. Methods.. Observational analytic cross sectional study involving 24 patients with allergic rhinitis who are willing to do blood draws and nasal mucosal secretions for examination levels of GM-CSF and eosinophil count. Results. Relationship of serum levels of GM-CSF, nasal mucosa GM-CSF, blood eosinophil count, and nasal mucosa eosinophil count with degree of allergic rhinitis was analyzed by correlation test p 0.05 so that re is no significant relationship. Relationship of serum levels of GM-CSF with nasal mucosa GM-CSF and relationship levels of nasal mucosa GM-CSF with nasal mucosa eosinophil count was analyzed by correlation test p 0.05 so that re is no significant relationship. Relationship of serum levels of GM-CSF with blood eosinophil count and relationship levels of nasal mucosa GM-CSF with nasal mucosal eosinophil count was analyzed by correlation test p 0.05 so that re is no significant relationship. Conclusions. re was no significant correlation between serum levels of GM-CSF, nasal mucosa GM-CSF, blood eosinophil count, and nasal mucosa eosinophil count with degree of allergic rhinitis. re was no significant correlation between serum levels of GM-CSF with nasal mucosa GM-CSF and between blood eosinophil count with nasal mucosal eosinophil count. re was no significant correlation between serum levels of GM-CSF with blood eosinophil count and between nasal mucosa GM-CSF with nasal mucosal eosinophil count.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.2/RAH/h/041311539 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system |
| Divisions: | Profesi Kedokteran > Spesialis Patologi Klinik, Fakultas Kedokteran |
| Depositing User: | Hasbi |
| Date Deposited: | 07 Apr 2014 09:14 |
| Last Modified: | 07 Apr 2014 09:14 |
| URI: | http://repository.ub.ac.id/id/eprint/158301 |
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